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- W2156817995 abstract "Our results were predicted by a general hypothesis [discussed in detail elsewhere (6, 7)] for the pathogenesis of recurrent herpetic disease in humans. To summarize, pri mary infection in man is postulated to result initially in viral replication in epithelial cells, with subsequent invasion of superficial nerve endings. The virus would then travel centripetally in sensory nerves, ultimately reaching ganglia, where it would induce a latent infection. Upon activation, the virus would travel centrifugally in the nerve trunk to the epithelium where vesicles are produced. Between exacerba tions of clinically apparent disease, the virus could be maintained in ganglionic cells by alternative mechanisms which Roizman (7) has designated the and the hypotheses. According to the dynamic state hypothesis, latent infection would be maintained by continued replication of a small but constant amount of infectious virus in one or several types of ganglionic cell. Extension of the infection would be inhibited by the presence of circulating antibody, specific immune lym phocytes and, possibly, Interferon. In the static state hypothesis, herpes simplex virus would be maintained in virogenic cells, with complete viral replication reversibly interrupted at an early stage in the cycle. As is noted below, our present results are consistent with the static state hypothesis." @default.
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- W2156817995 date "1973-06-01" @default.
- W2156817995 modified "2023-10-03" @default.
- W2156817995 title "Latent infections induced by herpes simplex viruses." @default.
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