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- W2156820761 abstract "Cells of the epidermis renew constantly from germinal layer stem cells. Although epithelial cell differentiation has been studied in great detail and the role of Wnt signaling in this process is well described, the contribution of epidermal Wnt secretion in epithelial cell homeostasis remains poorly understood. To analyze the role of Wnt proteins in this process, we created a conditional knockout allele of the Wnt cargo receptor Evi/Gpr177/Wntless and studied mice that lacked Evi expression in the epidermis. We found that K14-Cre, Evi-LOF mice lost their hair during the first hair cycle, showing a reddish skin with impaired skin barrier function. Expression profiling of mutant and wild-type skin revealed up-regulation of inflammation-associated genes. Furthermore, we found that Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis. Immune cell infiltration was detected in Evi-LOF skin. Interestingly, an age-dependent depletion of dendritic epidermal T cells (DETCs) and an infiltration of γδ(low) T cells in Evi mutant epidermis was observed. Collectively, the described inflammatory skin phenotype in Evi-deficient mice revealed an essential role of Wnt secretion in maintaining normal skin homeostasis by enabling a balanced epidermal-dermal cross talk, which affects immune cell recruitment and DETC survival." @default.
- W2156820761 created "2016-06-24" @default.
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- W2156820761 date "2013-08-05" @default.
- W2156820761 modified "2023-10-14" @default.
- W2156820761 title "Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis" @default.
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- W2156820761 doi "https://doi.org/10.1084/jem.20121871" @default.
- W2156820761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3754868" @default.
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- W2156820761 hasPublicationYear "2013" @default.
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