FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156822877> ?p ?o ?g. }

• W2156822877 endingPage "176" @default.
• W2156822877 startingPage "171" @default.
• W2156822877 abstract "Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treatment of diseases that are characterized by abnormal formation of blood vessels such as certain cancers and age-related macular degeneration. In addition, dysregulated angiogenesis has been observed in inflammatory diseases and might underly chronic cutaneous inflammation in psoriasis. Several experimental studies and clinical reports suggest that VEGF is involved in psoriasis pathogenesis. Among those, transgenic over-expression of VEGF in keratinocytes in mice resulted in skin inflammation and a phenotype resembling human psoriasis. In different psoriasis models, anti-VEGF antibody treatment of mice, already displaying disease symptoms, resulted in an overall improvement of the cutaneous lesions. On the molecular level human keratinocytes produce VEGF after stimulation with cytokines involved in psoriasis pathogenesis. Finally, patients with psoriasis receiving anti-VEGF treatment for cancer showed complete remission of their cutaneous symptoms. Therefore, VEGF might be an underappreciated pro-inflammatory factor in the pathogenesis of psoriasis. In this review, current knowledge on the significance of VEGF in psoriasis pathogenesis is summarized. Furthermore, current reports on treatments directed against VEGF or its receptors and their potential as future therapy for psoriasis are discussed." @default.
• W2156822877 created "2016-06-24" @default.
• W2156822877 creator A5017486300 @default.
• W2156822877 creator A5029938782 @default.
• W2156822877 creator A5037531417 @default.
• W2156822877 creator A5080318472 @default.
• W2156822877 date "2010-06-01" @default.
• W2156822877 modified "2023-10-09" @default.
• W2156822877 title "Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis—A possible target for novel therapies?" @default.
• W2156822877 cites W1506218223 @default.
• W2156822877 cites W1782747004 @default.
• W2156822877 cites W1914199395 @default.
• W2156822877 cites W1964141484 @default.
• W2156822877 cites W1965385471 @default.
• W2156822877 cites W1965939361 @default.
• W2156822877 cites W1974872231 @default.
• W2156822877 cites W1979196227 @default.
• W2156822877 cites W1988477431 @default.
• W2156822877 cites W1992409739 @default.
• W2156822877 cites W1995177178 @default.
• W2156822877 cites W2000000541 @default.
• W2156822877 cites W2000176833 @default.
• W2156822877 cites W2000292756 @default.
• W2156822877 cites W2015460060 @default.
• W2156822877 cites W2020845827 @default.
• W2156822877 cites W2033275545 @default.
• W2156822877 cites W2035371785 @default.
• W2156822877 cites W2043863730 @default.
• W2156822877 cites W2044914812 @default.
• W2156822877 cites W2053272214 @default.
• W2156822877 cites W2066045739 @default.
• W2156822877 cites W2069968649 @default.
• W2156822877 cites W2071972670 @default.
• W2156822877 cites W2080090843 @default.
• W2156822877 cites W2084380710 @default.
• W2156822877 cites W2102374546 @default.
• W2156822877 cites W2105786952 @default.
• W2156822877 cites W2118378313 @default.
• W2156822877 cites W2120975662 @default.
• W2156822877 cites W2121039615 @default.
• W2156822877 cites W2136991389 @default.
• W2156822877 cites W2140694423 @default.
• W2156822877 cites W2149022385 @default.
• W2156822877 cites W2150732175 @default.
• W2156822877 cites W2151911852 @default.
• W2156822877 cites W2153886574 @default.
• W2156822877 cites W2161829535 @default.
• W2156822877 cites W2170935967 @default.
• W2156822877 cites W2171998177 @default.
• W2156822877 cites W2395003662 @default.
• W2156822877 cites W250723341 @default.
• W2156822877 cites W2561759163 @default.
• W2156822877 doi "https://doi.org/10.1016/j.jdermsci.2010.03.023" @default.
• W2156822877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20430590" @default.
• W2156822877 hasPublicationYear "2010" @default.
• W2156822877 type Work @default.
• W2156822877 sameAs 2156822877 @default.
• W2156822877 citedByCount "91" @default.
• W2156822877 countsByYear W21568228772012 @default.
• W2156822877 countsByYear W21568228772013 @default.
• W2156822877 countsByYear W21568228772014 @default.
• W2156822877 countsByYear W21568228772015 @default.
• W2156822877 countsByYear W21568228772016 @default.
• W2156822877 countsByYear W21568228772017 @default.
• W2156822877 countsByYear W21568228772018 @default.
• W2156822877 countsByYear W21568228772019 @default.
• W2156822877 countsByYear W21568228772020 @default.
• W2156822877 countsByYear W21568228772021 @default.
• W2156822877 countsByYear W21568228772022 @default.
• W2156822877 countsByYear W21568228772023 @default.
• W2156822877 crossrefType "journal-article" @default.
• W2156822877 hasAuthorship W2156822877A5017486300 @default.
• W2156822877 hasAuthorship W2156822877A5029938782 @default.
• W2156822877 hasAuthorship W2156822877A5037531417 @default.
• W2156822877 hasAuthorship W2156822877A5080318472 @default.
• W2156822877 hasConcept C142724271 @default.
• W2156822877 hasConcept C167734588 @default.
• W2156822877 hasConcept C203014093 @default.
• W2156822877 hasConcept C2776914184 @default.
• W2156822877 hasConcept C2777025900 @default.
• W2156822877 hasConcept C2780394083 @default.
• W2156822877 hasConcept C2780564577 @default.
• W2156822877 hasConcept C2780942790 @default.
• W2156822877 hasConcept C502942594 @default.
• W2156822877 hasConcept C71924100 @default.
• W2156822877 hasConceptScore W2156822877C142724271 @default.
• W2156822877 hasConceptScore W2156822877C167734588 @default.
• W2156822877 hasConceptScore W2156822877C203014093 @default.
• W2156822877 hasConceptScore W2156822877C2776914184 @default.
• W2156822877 hasConceptScore W2156822877C2777025900 @default.
• W2156822877 hasConceptScore W2156822877C2780394083 @default.
• W2156822877 hasConceptScore W2156822877C2780564577 @default.
• W2156822877 hasConceptScore W2156822877C2780942790 @default.
• W2156822877 hasConceptScore W2156822877C502942594 @default.
• W2156822877 hasConceptScore W2156822877C71924100 @default.
• W2156822877 hasIssue "3" @default.
• W2156822877 hasLocation W21568228771 @default.
• W2156822877 hasLocation W21568228772 @default.

• next