FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156825073> ?p ?o ?g. }

• W2156825073 endingPage "1333" @default.
• W2156825073 startingPage "1325" @default.
• W2156825073 abstract "Burkholderia cenocepacia is an important human pathogen in patients with cystic fibrosis (CF). Non-clinical reservoirs may play a role in the acquisition of infection, so it is important to evaluate the pathogenic potential of environmental B. cenocepacia isolates. In this study, we investigated the interactions of two environmental B. cenocepacia strains (Mex1 and MCII-168) with two bronchial epithelial cell lines, 16HBE14o− and CFBE41o−, which have a non-CF and a CF phenotype, respectively. The environmental strains showed a significantly lower level of invasion into both CF and non-CF cells in comparison with the clinical B. cenocepacia LMG16656T strain. Exposure of polarized CFBE41o− or 16HBE14o− cells to the environmental strains resulted in a significant reduction in transepithelial resistance (TER), comparable with that observed following exposure to the clinical strain. A different mechanism of tight junction disruption in CF versus non-CF epithelia was found. In the 16HBE41o− cells, the environmental strains resulted in a drop in TER without any apparent effect on tight junction proteins such as zonula occludens-1 (ZO-1). In contrast, in CF cells, the amount of ZO-1 and its localization were clearly altered by the presence of both the environmental strains, comparable with the effect of LMG16656. This study demonstrates that even if the environmental strains are significantly less invasive than the clinical strain, they have an effect on epithelial integrity comparable with that of the clinical strain. Finally, the tight junction regulatory protein ZO-1 appears to be more susceptible to the presence of environmental strains in CF cells than in cells which express a functional cystic fibrosis transmembrane regulator (CFTR)." @default.
• W2156825073 created "2016-06-24" @default.
• W2156825073 creator A5017109798 @default.
• W2156825073 creator A5020159299 @default.
• W2156825073 creator A5028416545 @default.
• W2156825073 creator A5046064422 @default.
• W2156825073 creator A5058683448 @default.
• W2156825073 creator A5059041659 @default.
• W2156825073 creator A5068518107 @default.
• W2156825073 creator A5070029418 @default.
• W2156825073 date "2012-05-01" @default.
• W2156825073 modified "2023-09-23" @default.
• W2156825073 title "Interaction of environmental Burkholderia cenocepacia strains with cystic fibrosis and non-cystic fibrosis bronchial epithelial cells in vitro" @default.
• W2156825073 cites W1489106364 @default.
• W2156825073 cites W1499247383 @default.
• W2156825073 cites W1779884267 @default.
• W2156825073 cites W1782235924 @default.
• W2156825073 cites W1888185978 @default.
• W2156825073 cites W1908108023 @default.
• W2156825073 cites W1967115789 @default.
• W2156825073 cites W1993789740 @default.
• W2156825073 cites W2005644246 @default.
• W2156825073 cites W2011340684 @default.
• W2156825073 cites W2012159765 @default.
• W2156825073 cites W2018718318 @default.
• W2156825073 cites W2023308352 @default.
• W2156825073 cites W2029878860 @default.
• W2156825073 cites W2034033183 @default.
• W2156825073 cites W2047256415 @default.
• W2156825073 cites W2057625458 @default.
• W2156825073 cites W2061872852 @default.
• W2156825073 cites W2067757858 @default.
• W2156825073 cites W2068688951 @default.
• W2156825073 cites W2068981717 @default.
• W2156825073 cites W2087080904 @default.
• W2156825073 cites W2087649080 @default.
• W2156825073 cites W2092014535 @default.
• W2156825073 cites W2096107132 @default.
• W2156825073 cites W2098806631 @default.
• W2156825073 cites W2105642553 @default.
• W2156825073 cites W2109638827 @default.
• W2156825073 cites W2112337824 @default.
• W2156825073 cites W2116809039 @default.
• W2156825073 cites W2123230988 @default.
• W2156825073 cites W2126006315 @default.
• W2156825073 cites W2126594199 @default.
• W2156825073 cites W2128716894 @default.
• W2156825073 cites W2130570789 @default.
• W2156825073 cites W2132666490 @default.
• W2156825073 cites W2143530682 @default.
• W2156825073 cites W2145658355 @default.
• W2156825073 cites W2148703390 @default.
• W2156825073 cites W2149341297 @default.
• W2156825073 cites W2149928655 @default.
• W2156825073 cites W2150232178 @default.
• W2156825073 cites W2153265302 @default.
• W2156825073 cites W2155564635 @default.
• W2156825073 cites W2157337544 @default.
• W2156825073 cites W2159204818 @default.
• W2156825073 cites W2165529552 @default.
• W2156825073 cites W2166144151 @default.
• W2156825073 cites W2169270251 @default.
• W2156825073 cites W2171862804 @default.
• W2156825073 cites W4240940294 @default.
• W2156825073 doi "https://doi.org/10.1099/mic.0.056986-0" @default.
• W2156825073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22322958" @default.
• W2156825073 hasPublicationYear "2012" @default.
• W2156825073 type Work @default.
• W2156825073 sameAs 2156825073 @default.
• W2156825073 citedByCount "13" @default.
• W2156825073 countsByYear W21568250732012 @default.
• W2156825073 countsByYear W21568250732013 @default.
• W2156825073 countsByYear W21568250732014 @default.
• W2156825073 countsByYear W21568250732015 @default.
• W2156825073 countsByYear W21568250732016 @default.
• W2156825073 countsByYear W21568250732017 @default.
• W2156825073 countsByYear W21568250732018 @default.
• W2156825073 countsByYear W21568250732022 @default.
• W2156825073 countsByYear W21568250732023 @default.
• W2156825073 crossrefType "journal-article" @default.
• W2156825073 hasAuthorship W2156825073A5017109798 @default.
• W2156825073 hasAuthorship W2156825073A5020159299 @default.
• W2156825073 hasAuthorship W2156825073A5028416545 @default.
• W2156825073 hasAuthorship W2156825073A5046064422 @default.
• W2156825073 hasAuthorship W2156825073A5058683448 @default.
• W2156825073 hasAuthorship W2156825073A5059041659 @default.
• W2156825073 hasAuthorship W2156825073A5068518107 @default.
• W2156825073 hasAuthorship W2156825073A5070029418 @default.
• W2156825073 hasConcept C105702510 @default.
• W2156825073 hasConcept C177779419 @default.
• W2156825073 hasConcept C202751555 @default.
• W2156825073 hasConcept C2776938444 @default.
• W2156825073 hasConcept C2777756538 @default.
• W2156825073 hasConcept C2777979451 @default.
• W2156825073 hasConcept C2778022156 @default.
• W2156825073 hasConcept C2780855054 @default.
• W2156825073 hasConcept C523546767 @default.
• W2156825073 hasConcept C54355233 @default.

• next