FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156826712> ?p ?o ?g. }

• W2156826712 endingPage "660" @default.
• W2156826712 startingPage "658" @default.
• W2156826712 abstract "CYP2A6 is an enzyme with a high ability to activate a nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to its potent and ultimate carcinogen. In the present study, we investigated the relationship between genetic polymorphism of CYP2A6 and lung cancer risk in a case-control study of Japanese subjects. Genotyping of the CYP2A6 gene in both healthy volunteers and lung cancer patients was conducted. The frequency with which the subjects carried homozygotes of the CYP2A6 gene deletion-type mutation (deletion), which causes lack of the enzyme activity, was lower in the lung cancer patients than in the healthy control subjects. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.25 (95% CI; 0.08–0.83) when the OR for the population with homozygotes of the CYP2A6 wild-type gene was defined as 1.00. In the allelic-base analysis, there was also a significant decrease in the OR for the deletion allele. These data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces lung cancer risk." @default.
• W2156826712 created "2016-06-24" @default.
• W2156826712 creator A5021070991 @default.
• W2156826712 creator A5045120486 @default.
• W2156826712 creator A5046425489 @default.
• W2156826712 creator A5052944299 @default.
• W2156826712 creator A5071696225 @default.
• W2156826712 creator A5073059621 @default.
• W2156826712 creator A5079043652 @default.
• W2156826712 creator A5082279708 @default.
• W2156826712 creator A5082354025 @default.
• W2156826712 creator A5083716273 @default.
• W2156826712 date "1999-08-01" @default.
• W2156826712 modified "2023-09-26" @default.
• W2156826712 title "CYP2A6 Gene Deletion Reduces Susceptibility to Lung Cancer" @default.
• W2156826712 cites W1997048544 @default.
• W2156826712 cites W2024171602 @default.
• W2156826712 cites W2025269545 @default.
• W2156826712 cites W2064682737 @default.
• W2156826712 cites W2064695558 @default.
• W2156826712 cites W2081021064 @default.
• W2156826712 cites W2134325441 @default.
• W2156826712 cites W3159825070 @default.
• W2156826712 doi "https://doi.org/10.1006/bbrc.1999.1089" @default.
• W2156826712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10441482" @default.
• W2156826712 hasPublicationYear "1999" @default.
• W2156826712 type Work @default.
• W2156826712 sameAs 2156826712 @default.
• W2156826712 citedByCount "159" @default.
• W2156826712 countsByYear W21568267122012 @default.
• W2156826712 countsByYear W21568267122013 @default.
• W2156826712 countsByYear W21568267122014 @default.
• W2156826712 countsByYear W21568267122015 @default.
• W2156826712 countsByYear W21568267122016 @default.
• W2156826712 countsByYear W21568267122017 @default.
• W2156826712 countsByYear W21568267122018 @default.
• W2156826712 countsByYear W21568267122019 @default.
• W2156826712 countsByYear W21568267122020 @default.
• W2156826712 countsByYear W21568267122021 @default.
• W2156826712 crossrefType "journal-article" @default.
• W2156826712 hasAuthorship W2156826712A5021070991 @default.
• W2156826712 hasAuthorship W2156826712A5045120486 @default.
• W2156826712 hasAuthorship W2156826712A5046425489 @default.
• W2156826712 hasAuthorship W2156826712A5052944299 @default.
• W2156826712 hasAuthorship W2156826712A5071696225 @default.
• W2156826712 hasAuthorship W2156826712A5073059621 @default.
• W2156826712 hasAuthorship W2156826712A5079043652 @default.
• W2156826712 hasAuthorship W2156826712A5082279708 @default.
• W2156826712 hasAuthorship W2156826712A5082354025 @default.
• W2156826712 hasAuthorship W2156826712A5083716273 @default.
• W2156826712 hasConcept C104317684 @default.
• W2156826712 hasConcept C114246631 @default.
• W2156826712 hasConcept C126322002 @default.
• W2156826712 hasConcept C135763542 @default.
• W2156826712 hasConcept C143998085 @default.
• W2156826712 hasConcept C156957248 @default.
• W2156826712 hasConcept C180754005 @default.
• W2156826712 hasConcept C196013638 @default.
• W2156826712 hasConcept C202751555 @default.
• W2156826712 hasConcept C2776256026 @default.
• W2156826712 hasConcept C31467283 @default.
• W2156826712 hasConcept C502942594 @default.
• W2156826712 hasConcept C54355233 @default.
• W2156826712 hasConcept C71924100 @default.
• W2156826712 hasConcept C86745063 @default.
• W2156826712 hasConcept C86803240 @default.
• W2156826712 hasConcept C87644729 @default.
• W2156826712 hasConceptScore W2156826712C104317684 @default.
• W2156826712 hasConceptScore W2156826712C114246631 @default.
• W2156826712 hasConceptScore W2156826712C126322002 @default.
• W2156826712 hasConceptScore W2156826712C135763542 @default.
• W2156826712 hasConceptScore W2156826712C143998085 @default.
• W2156826712 hasConceptScore W2156826712C156957248 @default.
• W2156826712 hasConceptScore W2156826712C180754005 @default.
• W2156826712 hasConceptScore W2156826712C196013638 @default.
• W2156826712 hasConceptScore W2156826712C202751555 @default.
• W2156826712 hasConceptScore W2156826712C2776256026 @default.
• W2156826712 hasConceptScore W2156826712C31467283 @default.
• W2156826712 hasConceptScore W2156826712C502942594 @default.
• W2156826712 hasConceptScore W2156826712C54355233 @default.
• W2156826712 hasConceptScore W2156826712C71924100 @default.
• W2156826712 hasConceptScore W2156826712C86745063 @default.
• W2156826712 hasConceptScore W2156826712C86803240 @default.
• W2156826712 hasConceptScore W2156826712C87644729 @default.
• W2156826712 hasFunder F4320309773 @default.
• W2156826712 hasFunder F4320320912 @default.
• W2156826712 hasFunder F4320321945 @default.
• W2156826712 hasIssue "3" @default.
• W2156826712 hasLocation W21568267121 @default.
• W2156826712 hasLocation W21568267122 @default.
• W2156826712 hasOpenAccess W2156826712 @default.
• W2156826712 hasPrimaryLocation W21568267121 @default.
• W2156826712 hasRelatedWork W121700474 @default.
• W2156826712 hasRelatedWork W2002717359 @default.
• W2156826712 hasRelatedWork W2033977600 @default.
• W2156826712 hasRelatedWork W2034179809 @default.
• W2156826712 hasRelatedWork W2047454406 @default.
• W2156826712 hasRelatedWork W2049165100 @default.

• next