FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156826845> ?p ?o ?g. }

• W2156826845 endingPage "1768" @default.
• W2156826845 startingPage "1760" @default.
• W2156826845 abstract "Oral administration of the omega-3 fatty acid eicosapentaenoic acid (EPA), as the free fatty acid (FFA), leads to EPA incorporation into, and reduced growth of, experimental colorectal cancer liver metastases (CRCLM).We performed a Phase II double-blind, randomised, placebo-controlled trial of EPA-FFA 2 g daily in patients undergoing liver resection surgery for CRCLM. The patients took EPA-FFA (n=43) or placebo (n=45) prior to surgery. The primary end-point was the CRCLM Ki67 proliferation index (PI). Secondary end-points included safety and tolerability of EPA-FFA, tumour fatty acid content and CD31-positive vascularity. We also analysed overall survival (OS) and disease-free survival (DFS).The median (range) duration of EPA-FFA treatment was 30 (12-65) days. Treatment groups were well matched with no significant difference in disease burden at surgery or preoperative chemotherapy. EPA-FFA treatment was well tolerated with no excess of postoperative complications. Tumour tissue from EPA-FFA-treated patients demonstrated a 40% increase in EPA content (p=0.0008), no difference in Ki67 PI, but reduced vascularity in 'EPA-naïve' individuals (p=0.075). EPA-FFA also demonstrated antiangiogenic activity in vitro. In the first 18 months after CRCLM resection, EPA-FFA-treated individuals obtained OS benefit compared with placebo, although early CRC recurrence rates were similar.EPA-FFA therapy is safe and well tolerated in patients with advanced CRC undergoing liver surgery. EPA-FFA may have antiangiogenic properties. Remarkably, limited preoperative treatment may provide postoperative OS benefit. Phase III clinical evaluation of prolonged EPA-FFA treatment in CRCLM patients is warranted.ClinicalTrials.gov NCT01070355." @default.
• W2156826845 created "2016-06-24" @default.
• W2156826845 creator A5007919521 @default.
• W2156826845 creator A5025019174 @default.
• W2156826845 creator A5053307546 @default.
• W2156826845 creator A5065638342 @default.
• W2156826845 creator A5069417785 @default.
• W2156826845 creator A5069663680 @default.
• W2156826845 creator A5072068569 @default.
• W2156826845 creator A5076428971 @default.
• W2156826845 creator A5076476732 @default.
• W2156826845 date "2014-01-27" @default.
• W2156826845 modified "2023-09-28" @default.
• W2156826845 title "Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid" @default.
• W2156826845 cites W1551518679 @default.
• W2156826845 cites W1554536030 @default.
• W2156826845 cites W1969925021 @default.
• W2156826845 cites W1970668118 @default.
• W2156826845 cites W1973186280 @default.
• W2156826845 cites W1989227483 @default.
• W2156826845 cites W1994335425 @default.
• W2156826845 cites W1996399542 @default.
• W2156826845 cites W2005581755 @default.
• W2156826845 cites W2007849159 @default.
• W2156826845 cites W2012538473 @default.
• W2156826845 cites W2048647257 @default.
• W2156826845 cites W2064358352 @default.
• W2156826845 cites W2074809571 @default.
• W2156826845 cites W2095762159 @default.
• W2156826845 cites W2107220802 @default.
• W2156826845 cites W2117214964 @default.
• W2156826845 cites W2121188954 @default.
• W2156826845 cites W2123142851 @default.
• W2156826845 cites W2127739809 @default.
• W2156826845 cites W2141885792 @default.
• W2156826845 cites W2148327508 @default.
• W2156826845 cites W2148463262 @default.
• W2156826845 cites W2183470202 @default.
• W2156826845 cites W2327515496 @default.
• W2156826845 doi "https://doi.org/10.1136/gutjnl-2013-306445" @default.
• W2156826845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24470281" @default.
• W2156826845 hasPublicationYear "2014" @default.
• W2156826845 type Work @default.
• W2156826845 sameAs 2156826845 @default.
• W2156826845 citedByCount "82" @default.
• W2156826845 countsByYear W21568268452014 @default.
• W2156826845 countsByYear W21568268452015 @default.
• W2156826845 countsByYear W21568268452016 @default.
• W2156826845 countsByYear W21568268452017 @default.
• W2156826845 countsByYear W21568268452018 @default.
• W2156826845 countsByYear W21568268452019 @default.
• W2156826845 countsByYear W21568268452020 @default.
• W2156826845 countsByYear W21568268452021 @default.
• W2156826845 countsByYear W21568268452022 @default.
• W2156826845 countsByYear W21568268452023 @default.
• W2156826845 crossrefType "journal-article" @default.
• W2156826845 hasAuthorship W2156826845A5007919521 @default.
• W2156826845 hasAuthorship W2156826845A5025019174 @default.
• W2156826845 hasAuthorship W2156826845A5053307546 @default.
• W2156826845 hasAuthorship W2156826845A5065638342 @default.
• W2156826845 hasAuthorship W2156826845A5069417785 @default.
• W2156826845 hasAuthorship W2156826845A5069663680 @default.
• W2156826845 hasAuthorship W2156826845A5072068569 @default.
• W2156826845 hasAuthorship W2156826845A5076428971 @default.
• W2156826845 hasAuthorship W2156826845A5076476732 @default.
• W2156826845 hasConcept C126322002 @default.
• W2156826845 hasConcept C134018914 @default.
• W2156826845 hasConcept C141071460 @default.
• W2156826845 hasConcept C142724271 @default.
• W2156826845 hasConcept C168563851 @default.
• W2156826845 hasConcept C185592680 @default.
• W2156826845 hasConcept C19038510 @default.
• W2156826845 hasConcept C197934379 @default.
• W2156826845 hasConcept C203092338 @default.
• W2156826845 hasConcept C204787440 @default.
• W2156826845 hasConcept C27081682 @default.
• W2156826845 hasConcept C2776091944 @default.
• W2156826845 hasConcept C2777171753 @default.
• W2156826845 hasConcept C2778375690 @default.
• W2156826845 hasConcept C3017514745 @default.
• W2156826845 hasConcept C543025807 @default.
• W2156826845 hasConcept C55493867 @default.
• W2156826845 hasConcept C71924100 @default.
• W2156826845 hasConcept C90924648 @default.
• W2156826845 hasConceptScore W2156826845C126322002 @default.
• W2156826845 hasConceptScore W2156826845C134018914 @default.
• W2156826845 hasConceptScore W2156826845C141071460 @default.
• W2156826845 hasConceptScore W2156826845C142724271 @default.
• W2156826845 hasConceptScore W2156826845C168563851 @default.
• W2156826845 hasConceptScore W2156826845C185592680 @default.
• W2156826845 hasConceptScore W2156826845C19038510 @default.
• W2156826845 hasConceptScore W2156826845C197934379 @default.
• W2156826845 hasConceptScore W2156826845C203092338 @default.
• W2156826845 hasConceptScore W2156826845C204787440 @default.
• W2156826845 hasConceptScore W2156826845C27081682 @default.
• W2156826845 hasConceptScore W2156826845C2776091944 @default.
• W2156826845 hasConceptScore W2156826845C2777171753 @default.
• W2156826845 hasConceptScore W2156826845C2778375690 @default.

• next