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- W2156827044 abstract "We would like to thank Dr. Fuss for his thoughtful comments on our study ( 1 Terahara A. Machida T. Kubo T. et al. Analysis of dose distribution in gamma knife radiosurgery for multiple targets. Int J Radiat Oncol Biol Phys. 2000; 47: 1431-1434 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar ). The main issue raised was that our composite dose distribution did not include the effect of all shots used in one treatment session; therefore there is still underestimation of the whole effect. As he described, limited-size dose matrix (7.5 × 7.5 × 7.5 cm) did not include all targets at one time. It is possible, however, to use shots not only inside the dose matrix but outside for dose calculation with Gamma Plan Version 4, if we set some weights for all shots, including ones outside the dose matrix as well as ones inside. Part of our analysis was done with Gamma Plan Version 5, which can handle multiple dose matrices at once; then we could include all shots in those multiple dose matrices. We adjusted the weights for all shots and the prescribed dose to make the calculated treatment time for each shot equal to the one in the noncomposite plan, in which the weights for the shots outside each matrix were set to zero. Then we could get the composite dose distribution with the effect of all shots used at the time of treatment. Therefore, we believe that the composite dose distribution that we calculated in our paper pretty well represents the dose distribution actually delivered to the patients, even though we neglected some other minor factors such as “shuttle dose,” which ranged from about 0.1 to 0.2 Gy ( 2 Ertl A. Zehetmayer M. Schoggl A. et al. Shuttle dose at the Vienna Leksell gamma knife. Phys Med Biol. 1998; 43: 1567-1578 Crossref PubMed Scopus (22) Google Scholar )." @default.
- W2156827044 created "2016-06-24" @default.
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- W2156827044 date "2001-03-01" @default.
- W2156827044 modified "2023-10-02" @default.
- W2156827044 title "In response to Dr. Fuss" @default.
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- W2156827044 doi "https://doi.org/10.1016/s0360-3016(00)01449-8" @default.
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