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• W2156827480 abstract "The eicosanoids are centrally involved in the onset and resolution of inflammatory processes. A key enzyme in eicosanoid biosynthesis during inflammation is group IVA phospholipase A 2 (also known as cytosolic phospholipase A 2α , cPLA 2 α). This enzyme is responsible for generating free arachidonic acid from membrane phospholipids. cPLA 2 α translocates to perinuclear membranes shortly after cell activation, in a process that is governed by the increased availability of intracellular Ca 2+ . However, cPLA 2 α also catalyzes membrane phospholipid hydrolysis in response to agonists that do not mobilize intracellular Ca 2+ . How cPLA 2 α interacts with membranes under these conditions is a major, still unresolved issue. Here, we report that phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P 2 ] promotes translocation of cPLA 2 α to perinuclear membranes of intact cells in a manner that is independent of rises in the intracellular Ca 2+ concentration. PtdIns(4,5)P 2 anchors the enzyme to perinuclear membranes and allows for a proper interaction with its phospholipid substrate to release arachidonic acid." @default.
• W2156827480 created "2016-06-24" @default.
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• W2156827480 date "2006-01-01" @default.
• W2156827480 modified "2023-10-15" @default.
• W2156827480 title "Phosphatidylinositol 4,5-Bisphosphate Anchors Cytosolic Group IVA Phospholipase A₂to Perinuclear Membranes and Decreases Its Calcium Requirement for Translocation in Live Cells" @default.
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• W2156827480 doi "https://doi.org/10.1091/mbc.e05-06-0545" @default.
• W2156827480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1345655" @default.
• W2156827480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16221889" @default.
• W2156827480 hasPublicationYear "2006" @default.
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