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- W2156829937 abstract "The poor oral bioavailability arising from poor aqueous solubility should make drug research and development more difficult. Various approaches have been developed with a focus on enhancement of the solubility, dissolution rate, and oral bioavailability of poorly water-soluble drugs. To complete development works within a limited amount of time, the establishment of a suitable formulation strategy should be a key consideration for the pharmaceutical development of poorly water-soluble drugs. In this article, viable formulation options are reviewed on the basis of the biopharmaceutics classification system of drug substances. The article describes the basic approaches for poorly water-soluble drugs, such as crystal modification, micronization, amorphization, self-emulsification, cyclodextrin complexation, and pH modification. Literature-based examples of the formulation options for poorly water-soluble compounds and their practical application to marketed products are also provided. Classification of drug candidates based on their biopharmaceutical properties can provide an indication of the difficulty of drug development works. A better understanding of the physicochemical and biopharmaceutical properties of drug substances and the limitations of each delivery option should lead to efficient formulation development for poorly water-soluble drugs." @default.
- W2156829937 created "2016-06-24" @default.
- W2156829937 creator A5027866181 @default.
- W2156829937 creator A5036721398 @default.
- W2156829937 creator A5051609821 @default.
- W2156829937 creator A5088074277 @default.
- W2156829937 creator A5090119449 @default.
- W2156829937 date "2011-11-01" @default.
- W2156829937 modified "2023-10-11" @default.
- W2156829937 title "Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications" @default.
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