Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156831682> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2156831682 endingPage "5576" @default.
- W2156831682 startingPage "5573" @default.
- W2156831682 abstract "ABSTRACT Toxoplasma gondii is an important pathogen in the central nervous system, causing a severe and often fatal encephalitis in patients with AIDS. Gamma interferon (IFN-γ) is the main cytokine preventing reactivation of Toxoplasma encephalitis in the brain. Microglia are important IFN-γ-activated effector cells controlling the growth of T. gondii in the brain via a nitric oxide (NO)-mediated mechanism. IFN-γ can also activate astrocytes to inhibit the growth of T. gondii . Previous studies found that the mechanism in murine astrocytes is independent of NO and all other known anti- Toxoplasma mechanisms. In this study we investigated the role of IGTP , a recently identified IFN-γ-regulated gene, in IFN-γ inhibition of T. gondii in murine astrocytes. Primary astrocytes were cultivated from IGTP-deficient mice, treated with IFN-γ, and then tested for anti- Toxoplasma activity. In wild-type astrocytes T. gondii growth was significantly inhibited by IFN-γ, whereas in astrocytes from IGTP-deficient mice IFN-γ did not cause a significant inhibition of growth. Immunoblot analysis confirmed that IFN-γ induced significant levels of IGTP in wild-type murine astrocytes within 24 h. These results indicate that IGTP plays a central role in the IFN-γ-induced inhibition of T. gondii in murine astrocytes." @default.
- W2156831682 created "2016-06-24" @default.
- W2156831682 creator A5001110524 @default.
- W2156831682 creator A5062871652 @default.
- W2156831682 creator A5066856917 @default.
- W2156831682 date "2001-09-01" @default.
- W2156831682 modified "2023-10-14" @default.
- W2156831682 title "Gamma Interferon-Induced Inhibition of <i>Toxoplasma gondii</i> in Astrocytes Is Mediated by IGTP" @default.
- W2156831682 cites W1974401900 @default.
- W2156831682 cites W1992339724 @default.
- W2156831682 cites W1998047654 @default.
- W2156831682 cites W2010708956 @default.
- W2156831682 cites W2028101530 @default.
- W2156831682 cites W2029149797 @default.
- W2156831682 cites W2071990248 @default.
- W2156831682 cites W2074370296 @default.
- W2156831682 cites W2125722420 @default.
- W2156831682 cites W2132909642 @default.
- W2156831682 cites W2134768631 @default.
- W2156831682 cites W2141981735 @default.
- W2156831682 cites W2145267943 @default.
- W2156831682 cites W2145330496 @default.
- W2156831682 cites W2162641910 @default.
- W2156831682 cites W2167049054 @default.
- W2156831682 doi "https://doi.org/10.1128/iai.69.9.5573-5576.2001" @default.
- W2156831682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/98671" @default.
- W2156831682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11500431" @default.
- W2156831682 hasPublicationYear "2001" @default.
- W2156831682 type Work @default.
- W2156831682 sameAs 2156831682 @default.
- W2156831682 citedByCount "139" @default.
- W2156831682 countsByYear W21568316822012 @default.
- W2156831682 countsByYear W21568316822013 @default.
- W2156831682 countsByYear W21568316822014 @default.
- W2156831682 countsByYear W21568316822015 @default.
- W2156831682 countsByYear W21568316822016 @default.
- W2156831682 countsByYear W21568316822017 @default.
- W2156831682 countsByYear W21568316822018 @default.
- W2156831682 countsByYear W21568316822019 @default.
- W2156831682 countsByYear W21568316822020 @default.
- W2156831682 countsByYear W21568316822021 @default.
- W2156831682 countsByYear W21568316822022 @default.
- W2156831682 countsByYear W21568316822023 @default.
- W2156831682 crossrefType "journal-article" @default.
- W2156831682 hasAuthorship W2156831682A5001110524 @default.
- W2156831682 hasAuthorship W2156831682A5062871652 @default.
- W2156831682 hasAuthorship W2156831682A5066856917 @default.
- W2156831682 hasBestOaLocation W21568316822 @default.
- W2156831682 hasConcept C159047783 @default.
- W2156831682 hasConcept C159654299 @default.
- W2156831682 hasConcept C169760540 @default.
- W2156831682 hasConcept C203014093 @default.
- W2156831682 hasConcept C2776178377 @default.
- W2156831682 hasConcept C2776914184 @default.
- W2156831682 hasConcept C2777542381 @default.
- W2156831682 hasConcept C2778128430 @default.
- W2156831682 hasConcept C2778690821 @default.
- W2156831682 hasConcept C2779830541 @default.
- W2156831682 hasConcept C2780841837 @default.
- W2156831682 hasConcept C2780884517 @default.
- W2156831682 hasConcept C51785407 @default.
- W2156831682 hasConcept C529278444 @default.
- W2156831682 hasConcept C86803240 @default.
- W2156831682 hasConceptScore W2156831682C159047783 @default.
- W2156831682 hasConceptScore W2156831682C159654299 @default.
- W2156831682 hasConceptScore W2156831682C169760540 @default.
- W2156831682 hasConceptScore W2156831682C203014093 @default.
- W2156831682 hasConceptScore W2156831682C2776178377 @default.
- W2156831682 hasConceptScore W2156831682C2776914184 @default.
- W2156831682 hasConceptScore W2156831682C2777542381 @default.
- W2156831682 hasConceptScore W2156831682C2778128430 @default.
- W2156831682 hasConceptScore W2156831682C2778690821 @default.
- W2156831682 hasConceptScore W2156831682C2779830541 @default.
- W2156831682 hasConceptScore W2156831682C2780841837 @default.
- W2156831682 hasConceptScore W2156831682C2780884517 @default.
- W2156831682 hasConceptScore W2156831682C51785407 @default.
- W2156831682 hasConceptScore W2156831682C529278444 @default.
- W2156831682 hasConceptScore W2156831682C86803240 @default.
- W2156831682 hasIssue "9" @default.
- W2156831682 hasLocation W21568316821 @default.
- W2156831682 hasLocation W21568316822 @default.
- W2156831682 hasOpenAccess W2156831682 @default.
- W2156831682 hasPrimaryLocation W21568316821 @default.
- W2156831682 hasRelatedWork W1915977580 @default.
- W2156831682 hasRelatedWork W1988359488 @default.
- W2156831682 hasRelatedWork W2036224773 @default.
- W2156831682 hasRelatedWork W2045470312 @default.
- W2156831682 hasRelatedWork W2093075553 @default.
- W2156831682 hasRelatedWork W2125437109 @default.
- W2156831682 hasRelatedWork W2313048608 @default.
- W2156831682 hasRelatedWork W2884391850 @default.
- W2156831682 hasRelatedWork W2897422929 @default.
- W2156831682 hasRelatedWork W3029100624 @default.
- W2156831682 hasVolume "69" @default.
- W2156831682 isParatext "false" @default.
- W2156831682 isRetracted "false" @default.
- W2156831682 magId "2156831682" @default.
- W2156831682 workType "article" @default.