FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156832375> ?p ?o ?g. }

• W2156832375 endingPage "11" @default.
• W2156832375 startingPage "11" @default.
• W2156832375 abstract "Purpose/Objective: Adoption of the ASTRO Consensus Statement on PSA After Radiation Therapy has been critical in evaluating and comparing outcome following treatment with radiation. However, since its near universal adoption, several points have remained controversial, notably backdating the date of failure (DOF) to the point midway between the post-treatment PSA nadir and the first rise. The purposes of this study is to evaluate the impact of backdating on bNED (biochemical no evidence of disease) control and suggest changes in the definition, which can modify the influence of backdating on bNED control. Materials/Methods: Between 4/1/1989 and 11/30/1998, 1017 patients with non-metastatic prostate cancer were treated with 3D Conformal Radiation Therapy (3DCRT) alone. No patient received hormonal therapy prior to, during, or after radiotherapy unless local, distant, or biochemical failure was documented. bNED control was defined using the ASTRO Consensus definition. bNED failure was the time midway between the post-treatment PSA nadir and the first of the three consecutive rises in PSA. To evaluate the impact of backdating on bNED control, two alternate failure time-points were chosen, backdating to the first rise in PSA after nadir versus using the third post-treatment PSA rise. To further evaluate the impact of follow-up time on outcome, a subset analysis of 480 patients treated between 4/1/1989 and 11/30/1994 was evaluated. bNED control was estimated univariately using Kaplan-Meier methodology and comparisons in failure times were based on paired t-tests. Patients were also stratified by prognosis: favorable (PSA < 10, Gleason score [GS] 2–6, T1c/T2a), intermediate (not favorable or unfavorable), and unfavorable (T3, PSA > 20 or GS 8–10). The median follow-up was 53 months (range: 2 to 144 months) for the entire group and 74 months (range: 2 to 144 months) for the subset. Results: The 10-year actuarial bNED control rate was 66%, 59%, and 31% using the ASTRO definition, 1st rise and 3rd rise, respectively. Differences between the 3rd rise and other 2 definitions were statistically significant (p < 0.001). These differences persisted when patients were stratified by prognostic group (favorable: 81%, 77%, 55%; intermediate: 66%, 59%, 36%; unfavorable: 50%, 41%, 10%). These same differences in bNED control were observed for the long-term follow-up subset- 10-year actuarial bNED control rate was 57%, 52%, and 32% using the ASTRO definition, 1st rise and 3rd rise, respectively. These differences were statistically significant (p < 0.001). Hazard functions were estimated to better characterize risk of failure over time for the 3 DOFs. Hazard analysis was also accomplished using two additional points: 1) between the 1st and 2nd rise, and 2) between the 2nd and 3rd rise. The hazard functions demonstrated that earlier failure dates (e.g., ASTRO definition) are associated with the highest risk of failure in the first four years following radiotherapy. Similarly, later failure dates result in the highest risk of biochemical failure at up to 8 years post-treatment. These trends were seen for all of the DOFs compared to the ASTRO definition. These differences persisted with the subset analysis. Conclusions: Adoption of the ASTRO consensus definition has been crucial in evaluating outcome in the radiation oncology community. However, modifications are necessary to improve the sensitivity and specificity of the definition by changing the DOF to the point of the first consecutive rise. This point is about midway between the post-treatment nadir and the point of the third consecutive rise although validation with large patient datasets will be necessary to confirm this modified consensus definition." @default.
• W2156832375 created "2016-06-24" @default.
• W2156832375 creator A5043554307 @default.
• W2156832375 creator A5049646055 @default.
• W2156832375 creator A5050591671 @default.
• W2156832375 creator A5063389942 @default.
• W2156832375 creator A5075320625 @default.
• W2156832375 creator A5089628955 @default.
• W2156832375 date "2002-10-01" @default.
• W2156832375 modified "2023-09-27" @default.
• W2156832375 title "Does backdating change outcome when the ASTRO definition of biochemical control is used in patients with clinically localized prostate cancer treated with 3D conformal radiation therapy alone" @default.
• W2156832375 doi "https://doi.org/10.1016/s0360-3016(02)03074-2" @default.
• W2156832375 hasPublicationYear "2002" @default.
• W2156832375 type Work @default.
• W2156832375 sameAs 2156832375 @default.
• W2156832375 citedByCount "3" @default.
• W2156832375 crossrefType "journal-article" @default.
• W2156832375 hasAuthorship W2156832375A5043554307 @default.
• W2156832375 hasAuthorship W2156832375A5049646055 @default.
• W2156832375 hasAuthorship W2156832375A5050591671 @default.
• W2156832375 hasAuthorship W2156832375A5063389942 @default.
• W2156832375 hasAuthorship W2156832375A5075320625 @default.
• W2156832375 hasAuthorship W2156832375A5089628955 @default.
• W2156832375 hasBestOaLocation W21568323751 @default.
• W2156832375 hasConcept C121608353 @default.
• W2156832375 hasConcept C126322002 @default.
• W2156832375 hasConcept C141071460 @default.
• W2156832375 hasConcept C2778311097 @default.
• W2156832375 hasConcept C2780192828 @default.
• W2156832375 hasConcept C509974204 @default.
• W2156832375 hasConcept C71924100 @default.
• W2156832375 hasConceptScore W2156832375C121608353 @default.
• W2156832375 hasConceptScore W2156832375C126322002 @default.
• W2156832375 hasConceptScore W2156832375C141071460 @default.
• W2156832375 hasConceptScore W2156832375C2778311097 @default.
• W2156832375 hasConceptScore W2156832375C2780192828 @default.
• W2156832375 hasConceptScore W2156832375C509974204 @default.
• W2156832375 hasConceptScore W2156832375C71924100 @default.
• W2156832375 hasIssue "2" @default.
• W2156832375 hasLocation W21568323751 @default.
• W2156832375 hasOpenAccess W2156832375 @default.
• W2156832375 hasPrimaryLocation W21568323751 @default.
• W2156832375 hasRelatedWork W1972032589 @default.
• W2156832375 hasRelatedWork W1982133341 @default.
• W2156832375 hasRelatedWork W1983759783 @default.
• W2156832375 hasRelatedWork W2034738338 @default.
• W2156832375 hasRelatedWork W2125640697 @default.
• W2156832375 hasRelatedWork W2248742349 @default.
• W2156832375 hasRelatedWork W2321033326 @default.
• W2156832375 hasRelatedWork W3003016887 @default.
• W2156832375 hasRelatedWork W3023724372 @default.
• W2156832375 hasRelatedWork W3029905168 @default.
• W2156832375 hasVolume "54" @default.
• W2156832375 isParatext "false" @default.
• W2156832375 isRetracted "false" @default.
• W2156832375 magId "2156832375" @default.
• W2156832375 workType "article" @default.