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- W2156832389 endingPage "2208" @default.
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- W2156832389 abstract "The Pseudomonas aeruginosa type III secretion system (T3SS) is known to be a very important virulence factor in acute human infections, but it is less important in maintaining chronic infections in which T3SS genes are downregulated. In vitro, the activation of T3SS expression involves a positive activating loop that acts on the transcriptional regulator ExsA. We have observed that in vivo T3SS expression is cell density-dependent in a manner that does not need known quorum-sensing (QS) signals. In addition, stationary-phase culture supernatants added to exponential-phase growing strains can inhibit T3SS expression. The analysis of transposon insertion mutants showed that the production of such T3SS-inhibiting signals might depend on tryptophan synthase and hence tryptophan, which is the precursor of signalling molecules such as indole-3-acetic acid (IAA), kynurenine and Pseudomonas quinolone signal (PQS). Commercially available tryptophan-derived molecules were tested for their role in the regulation of T3SS expression. At millimolar concentrations, IAA, 1-naphthalacetic acid (NAA) and 3-hydroxykynurenine inhibited T3SS expression. Inactivation of the tryptophan dioxygenase-encoding kynA gene resulted in a decrease in the T3SS-inhibiting activity of supernatants. These observations suggest that tryptophan catabolites are involved in the downregulation of T3SS expression in the transition from a low- to a high-cell-density state." @default.
- W2156832389 created "2016-06-24" @default.
- W2156832389 creator A5024015513 @default.
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- W2156832389 creator A5037967215 @default.
- W2156832389 creator A5053397127 @default.
- W2156832389 creator A5054854639 @default.
- W2156832389 creator A5055332542 @default.
- W2156832389 creator A5087639820 @default.
- W2156832389 date "2008-08-01" @default.
- W2156832389 modified "2023-09-24" @default.
- W2156832389 title "High-cell-density regulation of the Pseudomonas aeruginosa type III secretion system: implications for tryptophan catabolites" @default.
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- W2156832389 doi "https://doi.org/10.1099/mic.0.2007/013680-0" @default.
- W2156832389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18667553" @default.