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• W2156833595 startingPage "350" @default.
• W2156833595 abstract "A comparative study of peak shape, elution behavior, and resolution of 16 beta-blockers (acebutolol, alprenolol, atenolol, bisoprolol, carteolol, celiprolol, esmolol, labetalol, metoprolol, nadolol, oxprenolol, pindolol, practolol, propranolol, sotalol, and timolol) chromatographed with hybrid mobile phases of triethylamine (TEA)-acetonitrile and sodium dodecyl sulfate (SDS)-propanol is performed using conventional reversed-phase columns and isocratic elution. Both solvent modifiers (TEA and SDS) prevent the interaction of the basic drugs with the alkyl-bonded phase. However, the protection mechanisms of silanols on the packing are different. Whereas TEA associates with the silanol sites (blocking ion-exchange processes or repelling the solutes), the long hydrophobic chain of SDS is inserted in the bonded organic layer with the sulfate group protruding outside, which makes the stationary phase negatively charged. The effects of TEA, acetonitrile, SDS, and propanol on the elution strength, efficiency, peak asymmetry, and resolution are examined under an experimental design basis that is assisted by computer simulation to reach more general conclusions. The combination of improved peak shapes, larger selectivity, and a smaller range in retention among compounds of extreme polarity leads to the observation that a greater number of beta-blockers can be resolved with a hybrid micellar system." @default.
• W2156833595 created "2016-06-24" @default.
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• W2156833595 date "2003-08-01" @default.
• W2156833595 modified "2023-10-16" @default.
• W2156833595 title "Improvement of Peak Shape and Separation Performance of -Blockers in Conventional Reversed-Phase Columns Using Solvent Modifiers" @default.
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• W2156833595 doi "https://doi.org/10.1093/chromsci/41.7.350" @default.
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