FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156834504> ?p ?o ?g. }

• W2156834504 endingPage "1360" @default.
• W2156834504 startingPage "1357" @default.
• W2156834504 abstract "The EphA2 tyrosine kinase receptor is frequently overexpressed in ovarian cancer and this feature is predictive of poor clinical outcome. Preclinical investigation has also linked EphA2 with p53. In our present study, we examined EphA2 and p53 status (both expression and full-length mutation status) in 6 ovarian cell lines and 79 human ovarian cancers to determine potential associations. EphA2 was overexpressed in 80% of ovarian cancer cell lines and in 75% of clinical specimens. In particular, high levels of EphA2 occurred in 91% of tumors with p53 null mutations compared to 68% in tumors with wild-type or missense mutations (p=0.027). EphA2 expression did not relate to critical versus non-critical site missense p53 mutations or the location of mutations on specific p53 exons. We also demonstrated that while EphA2 and p53 can provide independent information regarding clinical status, the combination of EphA2 and p53 status can predict poor clinical outcome. In particular, the combination of EphA2 overexpression and p53 null status was associated with decreased overall patient survival and related to increased incidence of ascites and distant metastasis. Taken together, these data indicate a complex relationship between EphA2 and p53 that appears to regulate EphA2 expression and clinical outcome." @default.
• W2156834504 created "2016-06-24" @default.
• W2156834504 creator A5009442045 @default.
• W2156834504 creator A5011112601 @default.
• W2156834504 creator A5018891733 @default.
• W2156834504 creator A5019407817 @default.
• W2156834504 creator A5024497385 @default.
• W2156834504 creator A5032852468 @default.
• W2156834504 creator A5039017321 @default.
• W2156834504 creator A5057441533 @default.
• W2156834504 creator A5067490446 @default.
• W2156834504 creator A5072844231 @default.
• W2156834504 creator A5081617588 @default.
• W2156834504 date "2006-10-11" @default.
• W2156834504 modified "2023-10-16" @default.
• W2156834504 title "Analysis of EphA2 expression and mutant p53 in ovarian carcinoma" @default.
• W2156834504 cites W107500635 @default.
• W2156834504 cites W1482714567 @default.
• W2156834504 cites W1512634984 @default.
• W2156834504 cites W1524233852 @default.
• W2156834504 cites W1784787521 @default.
• W2156834504 cites W1916049020 @default.
• W2156834504 cites W1925841406 @default.
• W2156834504 cites W1981328354 @default.
• W2156834504 cites W1992642151 @default.
• W2156834504 cites W1997388033 @default.
• W2156834504 cites W2000981078 @default.
• W2156834504 cites W2023755033 @default.
• W2156834504 cites W2032019019 @default.
• W2156834504 cites W2034034974 @default.
• W2156834504 cites W2034073392 @default.
• W2156834504 cites W2039832404 @default.
• W2156834504 cites W2049547244 @default.
• W2156834504 cites W2050488331 @default.
• W2156834504 cites W2072455059 @default.
• W2156834504 cites W2074480887 @default.
• W2156834504 cites W2078638255 @default.
• W2156834504 cites W2079384901 @default.
• W2156834504 cites W2080889566 @default.
• W2156834504 cites W2081220090 @default.
• W2156834504 cites W2088852482 @default.
• W2156834504 cites W2093282771 @default.
• W2156834504 cites W2094161067 @default.
• W2156834504 cites W2101635479 @default.
• W2156834504 cites W2104580786 @default.
• W2156834504 cites W2107155755 @default.
• W2156834504 cites W2108172661 @default.
• W2156834504 cites W2114131126 @default.
• W2156834504 cites W2118277449 @default.
• W2156834504 cites W2129825215 @default.
• W2156834504 cites W2136591076 @default.
• W2156834504 cites W2144811267 @default.
• W2156834504 cites W2165844247 @default.
• W2156834504 cites W2415366846 @default.
• W2156834504 cites W2438799252 @default.
• W2156834504 doi "https://doi.org/10.4161/cbt.5.10.3225" @default.
• W2156834504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16969087" @default.
• W2156834504 hasPublicationYear "2006" @default.
• W2156834504 type Work @default.
• W2156834504 sameAs 2156834504 @default.
• W2156834504 citedByCount "21" @default.
• W2156834504 countsByYear W21568345042012 @default.
• W2156834504 countsByYear W21568345042014 @default.
• W2156834504 countsByYear W21568345042018 @default.
• W2156834504 countsByYear W21568345042021 @default.
• W2156834504 countsByYear W21568345042022 @default.
• W2156834504 crossrefType "journal-article" @default.
• W2156834504 hasAuthorship W2156834504A5009442045 @default.
• W2156834504 hasAuthorship W2156834504A5011112601 @default.
• W2156834504 hasAuthorship W2156834504A5018891733 @default.
• W2156834504 hasAuthorship W2156834504A5019407817 @default.
• W2156834504 hasAuthorship W2156834504A5024497385 @default.
• W2156834504 hasAuthorship W2156834504A5032852468 @default.
• W2156834504 hasAuthorship W2156834504A5039017321 @default.
• W2156834504 hasAuthorship W2156834504A5057441533 @default.
• W2156834504 hasAuthorship W2156834504A5067490446 @default.
• W2156834504 hasAuthorship W2156834504A5072844231 @default.
• W2156834504 hasAuthorship W2156834504A5081617588 @default.
• W2156834504 hasBestOaLocation W21568345041 @default.
• W2156834504 hasConcept C101544691 @default.
• W2156834504 hasConcept C104317684 @default.
• W2156834504 hasConcept C121608353 @default.
• W2156834504 hasConcept C126322002 @default.
• W2156834504 hasConcept C143065580 @default.
• W2156834504 hasConcept C143998085 @default.
• W2156834504 hasConcept C150582083 @default.
• W2156834504 hasConcept C170493617 @default.
• W2156834504 hasConcept C2779013556 @default.
• W2156834504 hasConcept C2780427987 @default.
• W2156834504 hasConcept C3019054536 @default.
• W2156834504 hasConcept C36823959 @default.
• W2156834504 hasConcept C501734568 @default.
• W2156834504 hasConcept C502942594 @default.
• W2156834504 hasConcept C54355233 @default.
• W2156834504 hasConcept C71924100 @default.
• W2156834504 hasConcept C75563809 @default.
• W2156834504 hasConcept C86803240 @default.
• W2156834504 hasConceptScore W2156834504C101544691 @default.

• next