Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156835130> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2156835130 abstract "Beta-thalassaemia is characterized by a decrease (β(+)) or absence (β(0)) in the synthesis of β-globin chains of human haemoglobin. The heterozygous state for β(+) or β(0) result in β-thalassaemia trait in which the hallmark is the presence of an elevated level of Haemoglobin (Hb) A(2) (α(2)δ(2)). In the past, the traditional methods such as cellulose acetate electrophoresis with elution and microcolumn chromatrography have been the techniques used by the majority of the laboratories in Malaysia for the estimation of (Hb) A(2) levels. The recommended method currently is high performance liquid chromatography which has only been introduced in a few laboratories in the country.To determine the cut-off level for (Hb) A(2) when estimated by high performance liquid chromatography (HPLC) in the diagnosis of classical beta-thalassaemia trait, a condition in the homozygous state that results in beta-thalassaemia major and red blood cell transfusion dependency.High performance liquid chromatography (HPLC) as a method for the measurement of (Hb) A(2) was rapid, and technically easy. A cut-off level of (Hb) A(2) >4.0 % predict the majority of carriers of classical beta-thalassaemia.A full blood count (FBC), together with red blood cell indices generated on an automated blood counter in conjunction with the measurement of Hb A(2) on the VARIANT-BioRad, an automated HPLC machine and the beta-thal short program is an appropriate approach for the screening and presumptive identification of carriers of classical beta-thalassaemia prior to DNA studies for definitive diagnosis. In carriers for classical beta-thalassaemia, the MCV and MCH are <75 fl and <27 pg respectively with a Hb A(2) cut-off level > 4.0% [range 5.9 (4.5-8.1)] on the VARIANT-BioRad." @default.
- W2156835130 created "2016-06-24" @default.
- W2156835130 creator A5000094534 @default.
- W2156835130 creator A5024285243 @default.
- W2156835130 creator A5052995327 @default.
- W2156835130 creator A5065284557 @default.
- W2156835130 date "2001-07-01" @default.
- W2156835130 modified "2023-09-25" @default.
- W2156835130 title "High performance liquid chromatography (HPLC) as a screening tool for classical Beta-thalassaemia trait in malaysia." @default.
- W2156835130 cites W132484415 @default.
- W2156835130 cites W159624177 @default.
- W2156835130 cites W1902540685 @default.
- W2156835130 cites W1976329147 @default.
- W2156835130 cites W2078729510 @default.
- W2156835130 cites W2100815156 @default.
- W2156835130 cites W2165404644 @default.
- W2156835130 cites W2337251349 @default.
- W2156835130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3413648" @default.
- W2156835130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22893759" @default.
- W2156835130 hasPublicationYear "2001" @default.
- W2156835130 type Work @default.
- W2156835130 sameAs 2156835130 @default.
- W2156835130 citedByCount "11" @default.
- W2156835130 countsByYear W21568351302013 @default.
- W2156835130 countsByYear W21568351302016 @default.
- W2156835130 countsByYear W21568351302017 @default.
- W2156835130 countsByYear W21568351302018 @default.
- W2156835130 countsByYear W21568351302020 @default.
- W2156835130 countsByYear W21568351302023 @default.
- W2156835130 crossrefType "journal-article" @default.
- W2156835130 hasAuthorship W2156835130A5000094534 @default.
- W2156835130 hasAuthorship W2156835130A5024285243 @default.
- W2156835130 hasAuthorship W2156835130A5052995327 @default.
- W2156835130 hasAuthorship W2156835130A5065284557 @default.
- W2156835130 hasConcept C104317684 @default.
- W2156835130 hasConcept C126322002 @default.
- W2156835130 hasConcept C179998833 @default.
- W2156835130 hasConcept C185592680 @default.
- W2156835130 hasConcept C2776053618 @default.
- W2156835130 hasConcept C2776597655 @default.
- W2156835130 hasConcept C2777566322 @default.
- W2156835130 hasConcept C2777799968 @default.
- W2156835130 hasConcept C2779134260 @default.
- W2156835130 hasConcept C2909410647 @default.
- W2156835130 hasConcept C43617362 @default.
- W2156835130 hasConcept C49105822 @default.
- W2156835130 hasConcept C54355233 @default.
- W2156835130 hasConcept C71924100 @default.
- W2156835130 hasConcept C86803240 @default.
- W2156835130 hasConceptScore W2156835130C104317684 @default.
- W2156835130 hasConceptScore W2156835130C126322002 @default.
- W2156835130 hasConceptScore W2156835130C179998833 @default.
- W2156835130 hasConceptScore W2156835130C185592680 @default.
- W2156835130 hasConceptScore W2156835130C2776053618 @default.
- W2156835130 hasConceptScore W2156835130C2776597655 @default.
- W2156835130 hasConceptScore W2156835130C2777566322 @default.
- W2156835130 hasConceptScore W2156835130C2777799968 @default.
- W2156835130 hasConceptScore W2156835130C2779134260 @default.
- W2156835130 hasConceptScore W2156835130C2909410647 @default.
- W2156835130 hasConceptScore W2156835130C43617362 @default.
- W2156835130 hasConceptScore W2156835130C49105822 @default.
- W2156835130 hasConceptScore W2156835130C54355233 @default.
- W2156835130 hasConceptScore W2156835130C71924100 @default.
- W2156835130 hasConceptScore W2156835130C86803240 @default.
- W2156835130 hasLocation W21568351301 @default.
- W2156835130 hasOpenAccess W2156835130 @default.
- W2156835130 hasPrimaryLocation W21568351301 @default.
- W2156835130 hasRelatedWork W1541109821 @default.
- W2156835130 hasRelatedWork W1915811171 @default.
- W2156835130 hasRelatedWork W2078729510 @default.
- W2156835130 hasRelatedWork W2310918484 @default.
- W2156835130 hasRelatedWork W2409997361 @default.
- W2156835130 hasRelatedWork W2913541645 @default.
- W2156835130 hasRelatedWork W3013402687 @default.
- W2156835130 isParatext "false" @default.
- W2156835130 isRetracted "false" @default.
- W2156835130 magId "2156835130" @default.
- W2156835130 workType "article" @default.