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- W2156836597 abstract "As a super-antigen, staphylococcal enterotoxin C2 (SEC2) stimulates the release of massive inflammatory cytokines such as interferon-gamma (IFN-γ), interleukin-1 (IL-1) and interleukin-2 (IL-2) which are documented to implicate osteoblast differentiation. In the present study, SEC2 was found to significantly improve the osteoblast differentiation by up-regulating BMP2 and Runx2/Cbfa1 expression. Interferon (IFN)-inducible gene IFI16, a co-activator of Runx2/Cbfa1, was also activated by SEC2 in the osteoblast differentiation. In addition, exogenous introduction of SEC2 stimulated OPG expression and suppressed RANKL, suggesting suppression of osteoclastogenesis in hMSCs. Therefore, our results displayed that SEC2 plays an important role in the commitment of MSC to the osteoblast and it might be a potential new therapeutic candidate for bone regeneration." @default.
- W2156836597 created "2016-06-24" @default.
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- W2156836597 date "2005-10-01" @default.
- W2156836597 modified "2023-09-24" @default.
- W2156836597 title "Rhitinis and Asthma: One Airway, One Disease" @default.
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- W2156836597 doi "https://doi.org/10.1016/s1579-2129(06)60285-1" @default.
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