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• W2156836629 abstract "Abstract Metabolite fingerprinting of Arabidopsis (Arabidopsis thaliana) mutants with known or predicted metabolic lesions was performed by 1H-nuclear magnetic resonance, Fourier transform infrared, and flow injection electrospray-mass spectrometry. Fingerprinting enabled processing of five times more plants than conventional chromatographic profiling and was competitive for discriminating mutants, other than those affected in only low-abundance metabolites. Despite their rapidity and complexity, fingerprints yielded metabolomic insights (e.g. that effects of single lesions were usually not confined to individual pathways). Among fingerprint techniques, 1H-nuclear magnetic resonance discriminated the most mutant phenotypes from the wild type and Fourier transform infrared discriminated the fewest. To maximize information from fingerprints, data analysis was crucial. One-third of distinctive phenotypes might have been overlooked had data models been confined to principal component analysis score plots. Among several methods tested, machine learning (ML) algorithms, namely support vector machine or random forest (RF) classifiers, were unsurpassed for phenotype discrimination. Support vector machines were often the best performing classifiers, but RFs yielded some particularly informative measures. First, RFs estimated margins between mutant phenotypes, whose relations could then be visualized by Sammon mapping or hierarchical clustering. Second, RFs provided importance scores for the features within fingerprints that discriminated mutants. These scores correlated with analysis of variance F values (as did Kruskal-Wallis tests, true- and false-positive measures, mutual information, and the Relief feature selection algorithm). ML classifiers, as models trained on one data set to predict another, were ideal for focused metabolomic queries, such as the distinctiveness and consistency of mutant phenotypes. Accessible software for use of ML in plant physiology is highlighted." @default.
• W2156836629 created "2016-06-24" @default.
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• W2156836629 date "2010-06-21" @default.
• W2156836629 modified "2023-09-30" @default.
• W2156836629 title "Enhancement of Plant Metabolite Fingerprinting by Machine Learning " @default.
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• W2156836629 doi "https://doi.org/10.1104/pp.109.150524" @default.
• W2156836629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2923910" @default.
• W2156836629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20566707" @default.
• W2156836629 hasPublicationYear "2010" @default.
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