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- W2156836896 abstract "Background: Lipidomic biomarkers will facilitate the development of novel anti-atherosclerotic therapies.Objective: To evaluate the responses of circulating biomarkers to simvastatin treatment.Methods: A randomized, cross-over study in men with mixed dyslipidaemia was used to compare effects of simvastatin 40 mg/day with placebo.Results: Plasma concentrations of nine fatty acids (FA; of 33 evaluated) were reduced significantly by simvastatin. No changes in the rates of FA synthesis or in hepatic lipase or lipoprotein lipase activities were apparent. Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels increased.Conclusion: We identified lipidomic biomarkers of simvastatin treatment effect that are consistent with statin inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase.Trial registration: ClinicalTrials.gov identifier: NCT00935259." @default.
- W2156836896 created "2016-06-24" @default.
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- W2156836896 date "2011-03-21" @default.
- W2156836896 modified "2023-10-04" @default.
- W2156836896 title "The effects of simvastatin treatment on plasma lipid-related biomarkers in men with dyslipidaemia" @default.
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- W2156836896 doi "https://doi.org/10.3109/1354750x.2011.561367" @default.
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