FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156842811> ?p ?o ?g. }

• W2156842811 abstract "The protein kinase inhibitor staurosporine elicits multiple responses in various systems. We evaluated nine naturally occurring staurosporine derivatives as modulators of chemokine production by monitoring the secretion of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) in the cell line NB-4. Several staurosporines increased, dose- and time-dependently, the IL-8 and MCP-1 concentration in the cell culture supernatants and three derivatives strongly inhibited proliferation of the NB-4 cells. By comparing the efficiency of these analogues at the same concentration, the lead compound staurosporine (STS-1) was the best inducer of chemokine secretion, whereas 3-hydroxystaurosporine (STS-3) was the most potent growth inhibitor. Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate (TPA) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells. Several staurosporine analogues clearly inhibited the TPA-induced but enhanced the TNFalpha-mediated chemokine increase. These effects, namely the increase of chemokines in untreated or TNFalpha-treated cells and the inhibition of chemokine release in TPA-treated cells, cannot be explained by the exclusive inhibition of protein kinase C (PKC). It may indicate that staurosporines are additionally involved in activation of the PKC-triggered chemokine production." @default.
• W2156842811 created "2016-06-24" @default.
• W2156842811 creator A5011231389 @default.
• W2156842811 creator A5018689307 @default.
• W2156842811 creator A5024767703 @default.
• W2156842811 creator A5040178005 @default.
• W2156842811 creator A5072676390 @default.
• W2156842811 date "2003-10-01" @default.
• W2156842811 modified "2023-10-03" @default.
• W2156842811 title "Differential effects of staurosporine and its analogues on chemokine release by promyelocytic leukemia cell line NB-4" @default.
• W2156842811 cites W1527712367 @default.
• W2156842811 cites W1553712313 @default.
• W2156842811 cites W1579490691 @default.
• W2156842811 cites W1586091913 @default.
• W2156842811 cites W1589866689 @default.
• W2156842811 cites W1589900156 @default.
• W2156842811 cites W1792340383 @default.
• W2156842811 cites W1963815040 @default.
• W2156842811 cites W1964508588 @default.
• W2156842811 cites W1967260070 @default.
• W2156842811 cites W1974520908 @default.
• W2156842811 cites W1977864608 @default.
• W2156842811 cites W1984038191 @default.
• W2156842811 cites W1990116192 @default.
• W2156842811 cites W1991764444 @default.
• W2156842811 cites W2001163176 @default.
• W2156842811 cites W2004578380 @default.
• W2156842811 cites W2018767744 @default.
• W2156842811 cites W2022934499 @default.
• W2156842811 cites W2026692684 @default.
• W2156842811 cites W2027568126 @default.
• W2156842811 cites W2042691139 @default.
• W2156842811 cites W2044563284 @default.
• W2156842811 cites W2045180580 @default.
• W2156842811 cites W2048895899 @default.
• W2156842811 cites W2052010120 @default.
• W2156842811 cites W2069855944 @default.
• W2156842811 cites W2074579157 @default.
• W2156842811 cites W2079866862 @default.
• W2156842811 cites W2085547973 @default.
• W2156842811 cites W2093333003 @default.
• W2156842811 cites W2139644267 @default.
• W2156842811 cites W2146339745 @default.
• W2156842811 cites W2160272188 @default.
• W2156842811 cites W2163411868 @default.
• W2156842811 cites W2167944112 @default.
• W2156842811 cites W2238865560 @default.
• W2156842811 cites W2415517761 @default.
• W2156842811 doi "https://doi.org/10.1016/s0145-2126(03)00047-x" @default.
• W2156842811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12860017" @default.
• W2156842811 hasPublicationYear "2003" @default.
• W2156842811 type Work @default.
• W2156842811 sameAs 2156842811 @default.
• W2156842811 citedByCount "2" @default.
• W2156842811 crossrefType "journal-article" @default.
• W2156842811 hasAuthorship W2156842811A5011231389 @default.
• W2156842811 hasAuthorship W2156842811A5018689307 @default.
• W2156842811 hasAuthorship W2156842811A5024767703 @default.
• W2156842811 hasAuthorship W2156842811A5040178005 @default.
• W2156842811 hasAuthorship W2156842811A5072676390 @default.
• W2156842811 hasConcept C13373296 @default.
• W2156842811 hasConcept C153911025 @default.
• W2156842811 hasConcept C17991360 @default.
• W2156842811 hasConcept C184235292 @default.
• W2156842811 hasConcept C185592680 @default.
• W2156842811 hasConcept C195794163 @default.
• W2156842811 hasConcept C203014093 @default.
• W2156842811 hasConcept C2776914184 @default.
• W2156842811 hasConcept C2778690821 @default.
• W2156842811 hasConcept C2779084600 @default.
• W2156842811 hasConcept C2781184567 @default.
• W2156842811 hasConcept C49039625 @default.
• W2156842811 hasConcept C502942594 @default.
• W2156842811 hasConcept C54355233 @default.
• W2156842811 hasConcept C55493867 @default.
• W2156842811 hasConcept C81885089 @default.
• W2156842811 hasConcept C86803240 @default.
• W2156842811 hasConcept C95444343 @default.
• W2156842811 hasConcept C98274493 @default.
• W2156842811 hasConceptScore W2156842811C13373296 @default.
• W2156842811 hasConceptScore W2156842811C153911025 @default.
• W2156842811 hasConceptScore W2156842811C17991360 @default.
• W2156842811 hasConceptScore W2156842811C184235292 @default.
• W2156842811 hasConceptScore W2156842811C185592680 @default.
• W2156842811 hasConceptScore W2156842811C195794163 @default.
• W2156842811 hasConceptScore W2156842811C203014093 @default.
• W2156842811 hasConceptScore W2156842811C2776914184 @default.
• W2156842811 hasConceptScore W2156842811C2778690821 @default.
• W2156842811 hasConceptScore W2156842811C2779084600 @default.
• W2156842811 hasConceptScore W2156842811C2781184567 @default.
• W2156842811 hasConceptScore W2156842811C49039625 @default.
• W2156842811 hasConceptScore W2156842811C502942594 @default.
• W2156842811 hasConceptScore W2156842811C54355233 @default.
• W2156842811 hasConceptScore W2156842811C55493867 @default.
• W2156842811 hasConceptScore W2156842811C81885089 @default.
• W2156842811 hasConceptScore W2156842811C86803240 @default.
• W2156842811 hasConceptScore W2156842811C95444343 @default.
• W2156842811 hasConceptScore W2156842811C98274493 @default.
• W2156842811 hasLocation W21568428111 @default.
• W2156842811 hasLocation W21568428112 @default.

• next