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- W2156842818 endingPage "440" @default.
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- W2156842818 abstract "Introduction: Proteins are effective biotherapeutics with applications in diverse ailments. Despite being specific and potent, their full clinical potential has not yet been realized. This can be attributed to short half-lives, complex structures, poor in vivo stability, low permeability, frequent parenteral administrations and poor adherence to treatment in chronic diseases. A sustained release system, providing controlled release of proteins, may overcome many of these limitations.Areas covered: This review focuses on recent development in approaches, especially polymer-based formulations, which can provide therapeutic levels of proteins over extended periods. Advances in particulate, gel-based formulations and novel approaches for extended protein delivery are discussed. Emphasis is placed on dosage form, method of preparation, mechanism of release and stability of biotherapeutics.Expert opinion: Substantial advancements have been made in the field of extended protein delivery via various polymer-based formulations over last decade despite the unique delivery-related challenges posed by protein biologics. A number of injectable sustained-release formulations have reached market. However, therapeutic application of proteins is still hampered by delivery-related issues. A large number of protein molecules are under clinical trials, and hence, there is an urgent need to develop new methods to deliver these highly potent biologics." @default.
- W2156842818 created "2016-06-24" @default.
- W2156842818 creator A5006916713 @default.
- W2156842818 creator A5040297353 @default.
- W2156842818 creator A5076948205 @default.
- W2156842818 creator A5091372294 @default.
- W2156842818 date "2014-09-24" @default.
- W2156842818 modified "2023-10-16" @default.
- W2156842818 title "Long-term delivery of protein therapeutics" @default.
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