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- W2156844985 abstract "Abstract A modification of the two-way mixed lymphocyte culture (MLC) for the assessment of immunosuppressive activity in human plasma is proposed. Adding 50% of plasma instead of 10% to micro MLC increases the sensitivity and decreases the variability of the system used for pharmacodynamic analysis of prednisoloneand azathioprine combined with prednisolone. Harvesting the cultures on Day 3 augments the area under the inhibition time curve when compared with Day 5 and reduces the variability of the response of the MLCs. The method provides a time dependent measure of immunosuppression which may be correlated with pharmacokinetic parameters." @default.
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- W2156844985 date "1980-01-01" @default.
- W2156844985 modified "2023-09-27" @default.
- W2156844985 title "Modification of the mixed lymphocyte reaction for pharmacokinetic assessment of immunosuppresive activity in human plasma" @default.
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- W2156844985 doi "https://doi.org/10.1016/0192-0561(80)90023-5" @default.
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