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• W2156847997 abstract "The subtype of the proliferating cells in the synovial fluid of patients with rheumatoid arthritis (RA), ankylopoietic spondylarthrosis (SPA), and osteoarthritis (OA) was studied with auto-radiography-immunoperoxidase double staining. Of all spontaneously proliferating synovial fluid cells in chronic arthritis, 59±4% displayed T8 differentiation marker, whereas T4 (21±4%) and B (2±1%) cells were few. Of all T4+ and all T8+ lymphocytes, 0.55±0.1% and 0.90±0.1%, respectively, incorporated [3H]thymidine. The [3H]thymidine labelling index for B cells was 0.30±0.1%. This was in contrast to OA, in which no proliferating lymphocytes were observed in the synovial fluid. Our findings suggest that the predominance of proliferating T8+ cells in the synovial fluid reflects an underlying chronic inflammation. Because RA and SPA synovium is a site of intense immunoglobulin production, our finding of the predominance of activated, proliferating T8+ cells may also reflect a dissociation between phenotype and function as a reason for the chronicity of the joint inflammation." @default.
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• W2156847997 date "1985-10-01" @default.
• W2156847997 modified "2023-10-17" @default.
• W2156847997 title "Proliferating Cells in the Synovial Fluid in Rheumatic Disease." @default.
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• W2156847997 doi "https://doi.org/10.1111/j.1365-3083.1985.tb01896.x" @default.
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