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• W2156848498 abstract "The potential use as a bone substitute material of a three-dimensional bioactive glass fiber scaffold composed of Na2O-K2O-MgO-CaO-B2O3-P2O5-SiO2 (BG1) was investigated in this work. Scaffolds were pre-treated with simulated body fluid (SBF) to promote the formation of two different bone-like apatite layers on their surfaces. The topography and roughness of the deposited layers were assessed by scanning electron microscopy (SEM), while the chemical composition and structure using X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy, respectively. Based on surface analysis, the bioactive glass surfaces were ranked from smoothest to roughest: 0 SBF (untreated), 1× SBF and 2× SBF. A calcium-deficient carbonated hydroxyapatite (HCA) layer was present on both SBF-treated scaffolds, with higher number and larger bone-like apatite nodule formation in the 2× SBF case. MC3T3-E1 preosteoblasts showed a more flattened morphology and higher cell proliferation on the nontreated scaffolds; whereas, cells were more elongated and had higher osteoblastic activity on SBF-treated samples. In vivo results in a rabbit calvarial bone defect model showed enhanced bone formation with SBF pretreated scaffolds, compared with untreated ones, commercially available Perioglass® particles and empty defects. Our findings demonstrate that the formation of a rough HCA layer on bioactive glass porous scaffolds enhanced preosteoblast maturation in vitro, as well as bone formation in vivo. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010." @default.
• W2156848498 created "2016-06-24" @default.
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• W2156848498 date "2010-01-01" @default.
• W2156848498 modified "2023-10-18" @default.
• W2156848498 title "Enhanced osteoblastic activity and bone regeneration using surface-modified porous bioactive glass scaffolds" @default.
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• W2156848498 doi "https://doi.org/10.1002/jbm.a.32773" @default.
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