FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156849764> ?p ?o ?g. }

• W2156849764 abstract "Endothelial progenitor cells (EPCs) play a critical role in restoration of ischemic diseases. However, the actual status of EPC development and the mechanisms of EPC dysfunctions in patients with various ischemic diseases remain unknown.To investigate the detailed function of EPCs in experimental murine models, we have established an EPC colony forming assay (EPC-CFA) in murine EPCs. The abilities of murine EPCs in differentiation, adhesive capacity, proliferative potency, and transplantation in vitro and in vivo were then examined.Peripheral blood mononuclear cells (PB-MNCs), bone marrow mononuclear cells (BM-MNCs) or bone marrow c-Kit+/Sca-1+ lineage negative (BM-KSL) cells differentiated into two types of EPC colony forming units (EPC-CFUs), large sized EPC (large-EPC)-CFUs and small sized EPC (small-EPC)-CFUs. Gene expression analysis demonstrated that both EPC-CFU-derived cells expressed eNOS, Flk-1 and VE-cadherin, markers of endothelial cells (ECs), although the small-EPCs derived from small-EPC-CFU were higher in number and showed more immature features (higher population of KSL cells). Functionally, the large-EPCs derived from large-EPC-CFU had higher adhesive capacity but lower proliferative potency than small-EPCs, showing improved tubular forming capacity and incorporation potency into primary EC-derived tube formation. Importantly, hindlimb ischemia increased the frequencies of large-EPC-CFUs differentiated from PB-MNCs and bone marrow. Actually, transplantation of large-EPCs into ischemic hindlimb enhanced neovascularization in hindlimb ischemia model, although small-EPCs or murine ECs did not, suggesting that large-EPC-CFUs might play an important role in restoration of ischemic diseases.We demonstrated, using a murine ischemia model, that the EPC-CFA could be a useful way to investigate the differentiation levels of murine EPCs, further providing a crucial clue that large-EPC-CFU status may be more functional or effective EPCs to promote neovascularization." @default.
• W2156849764 created "2016-06-24" @default.
• W2156849764 creator A5006471447 @default.
• W2156849764 creator A5010419763 @default.
• W2156849764 creator A5035591396 @default.
• W2156849764 creator A5061610581 @default.
• W2156849764 creator A5072081773 @default.
• W2156849764 creator A5072805794 @default.
• W2156849764 creator A5079342872 @default.
• W2156849764 date "2013-02-28" @default.
• W2156849764 modified "2023-10-08" @default.
• W2156849764 title "Identification of mouse colony-forming endothelial progenitor cells for postnatal neovascularization: a novel insight highlighted by new mouse colony-forming assay" @default.
• W2156849764 cites W143420532 @default.
• W2156849764 cites W1537192388 @default.
• W2156849764 cites W1967890082 @default.
• W2156849764 cites W1974812650 @default.
• W2156849764 cites W1979103623 @default.
• W2156849764 cites W1981428626 @default.
• W2156849764 cites W1982861439 @default.
• W2156849764 cites W1986991023 @default.
• W2156849764 cites W1988126593 @default.
• W2156849764 cites W1999579644 @default.
• W2156849764 cites W2020250111 @default.
• W2156849764 cites W2034916016 @default.
• W2156849764 cites W2034924908 @default.
• W2156849764 cites W2049466721 @default.
• W2156849764 cites W2051298035 @default.
• W2156849764 cites W2053704719 @default.
• W2156849764 cites W2098444281 @default.
• W2156849764 cites W2098767125 @default.
• W2156849764 cites W2107922629 @default.
• W2156849764 cites W2121602339 @default.
• W2156849764 cites W2127872440 @default.
• W2156849764 cites W2130761693 @default.
• W2156849764 cites W2140165420 @default.
• W2156849764 cites W2142041241 @default.
• W2156849764 cites W2142226770 @default.
• W2156849764 cites W2145524503 @default.
• W2156849764 cites W2145639716 @default.
• W2156849764 cites W2169083662 @default.
• W2156849764 doi "https://doi.org/10.1186/scrt168" @default.
• W2156849764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3706928" @default.
• W2156849764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23448126" @default.
• W2156849764 hasPublicationYear "2013" @default.
• W2156849764 type Work @default.
• W2156849764 sameAs 2156849764 @default.
• W2156849764 citedByCount "38" @default.
• W2156849764 countsByYear W21568497642014 @default.
• W2156849764 countsByYear W21568497642015 @default.
• W2156849764 countsByYear W21568497642016 @default.
• W2156849764 countsByYear W21568497642017 @default.
• W2156849764 countsByYear W21568497642018 @default.
• W2156849764 countsByYear W21568497642019 @default.
• W2156849764 countsByYear W21568497642020 @default.
• W2156849764 countsByYear W21568497642021 @default.
• W2156849764 countsByYear W21568497642022 @default.
• W2156849764 countsByYear W21568497642023 @default.
• W2156849764 crossrefType "journal-article" @default.
• W2156849764 hasAuthorship W2156849764A5006471447 @default.
• W2156849764 hasAuthorship W2156849764A5010419763 @default.
• W2156849764 hasAuthorship W2156849764A5035591396 @default.
• W2156849764 hasAuthorship W2156849764A5061610581 @default.
• W2156849764 hasAuthorship W2156849764A5072081773 @default.
• W2156849764 hasAuthorship W2156849764A5072805794 @default.
• W2156849764 hasAuthorship W2156849764A5079342872 @default.
• W2156849764 hasBestOaLocation W21568497641 @default.
• W2156849764 hasConcept C123012128 @default.
• W2156849764 hasConcept C126322002 @default.
• W2156849764 hasConcept C137061746 @default.
• W2156849764 hasConcept C16685009 @default.
• W2156849764 hasConcept C192285135 @default.
• W2156849764 hasConcept C201750760 @default.
• W2156849764 hasConcept C202751555 @default.
• W2156849764 hasConcept C203014093 @default.
• W2156849764 hasConcept C2778271429 @default.
• W2156849764 hasConcept C2780007613 @default.
• W2156849764 hasConcept C2780152582 @default.
• W2156849764 hasConcept C2780394083 @default.
• W2156849764 hasConcept C28328180 @default.
• W2156849764 hasConcept C2908647359 @default.
• W2156849764 hasConcept C2911091166 @default.
• W2156849764 hasConcept C502942594 @default.
• W2156849764 hasConcept C523546767 @default.
• W2156849764 hasConcept C54355233 @default.
• W2156849764 hasConcept C55493867 @default.
• W2156849764 hasConcept C71924100 @default.
• W2156849764 hasConcept C86803240 @default.
• W2156849764 hasConcept C95444343 @default.
• W2156849764 hasConcept C99454951 @default.
• W2156849764 hasConceptScore W2156849764C123012128 @default.
• W2156849764 hasConceptScore W2156849764C126322002 @default.
• W2156849764 hasConceptScore W2156849764C137061746 @default.
• W2156849764 hasConceptScore W2156849764C16685009 @default.
• W2156849764 hasConceptScore W2156849764C192285135 @default.
• W2156849764 hasConceptScore W2156849764C201750760 @default.
• W2156849764 hasConceptScore W2156849764C202751555 @default.
• W2156849764 hasConceptScore W2156849764C203014093 @default.
• W2156849764 hasConceptScore W2156849764C2778271429 @default.
• W2156849764 hasConceptScore W2156849764C2780007613 @default.
• W2156849764 hasConceptScore W2156849764C2780152582 @default.

• next