FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156850323> ?p ?o ?g. }

• W2156850323 abstract "Depression is prevalent in people with type 2 diabetes and affects both glycemic control and overall quality of life. The aim of this trial was to evaluate the effect of the antidepressant paroxetine on metabolic control, quality of life and mental well-being in mildly depressed women with type 2 diabetes. We randomised 15 mildly depressed women with non-optimally controlled type 2 diabetes to a 10-week single-blind treatment with either paroxetine 20 mg per day or placebo. Primary efficacy measurements were glycemic control and quality of life. Glycosylated hemoglobin A1c (GHbA1c) was used as a measure of glycemic control. Quality of life was evaluated using RAND-36. Mental state was assessed using two clinician-rated scoring instruments, Hamilton's Anxiety Scale (HAM-A) and Montgomery-Åsberg's Depression Rating Scale (MADRS), and a patient-rated scoring instrument, Beck's Depression Inventory (BDI). At the end of the study no significant difference between groups in improvement of quality of life was found. A trend towards a superior improvement in glycemic control was found in the paroxetine group (p = 0.08). A superior increase in sex-hormone-binding-globuline (SHBG) levels was evidenced in the paroxetine group (p = 0.01) as a sign of improved insulin sensitivity. There was also a trend for superior efficacy of paroxetine in investigator-rated anxiety and depression. This notion was supported by a trend for superior decrease of serum cortisol levels in the paroxetine group (p = 0.06). Paroxetine has a beneficial effect on measures of insulin sensitivity and may improve glycemic control. Larger studies of longer duration are needed to verify the benefits of paroxetine in type 2 diabetes. While waiting for more conclusive evidence it seems sensible to augment standard care of type 2 diabetes with paroxetine even in patients who do not fulfil routine psychiatric criteria for initiation of antidepressant drug treatment." @default.
• W2156850323 created "2016-06-24" @default.
• W2156850323 creator A5011338575 @default.
• W2156850323 creator A5024592659 @default.
• W2156850323 creator A5048912647 @default.
• W2156850323 date "2003-05-14" @default.
• W2156850323 modified "2023-09-26" @default.
• W2156850323 title "Quality of life and metabolic status in mildly depressed women with type 2 diabetes treated with paroxetine: A single-blind randomised placebo controlled trial" @default.
• W2156850323 cites W154165041 @default.
• W2156850323 cites W1821822345 @default.
• W2156850323 cites W1970457276 @default.
• W2156850323 cites W1991292047 @default.
• W2156850323 cites W2016582678 @default.
• W2156850323 cites W2030396551 @default.
• W2156850323 cites W2067495470 @default.
• W2156850323 cites W2067958701 @default.
• W2156850323 cites W2117020897 @default.
• W2156850323 cites W2128759000 @default.
• W2156850323 cites W2131823335 @default.
• W2156850323 cites W2140937253 @default.
• W2156850323 cites W2147240869 @default.
• W2156850323 cites W2190373369 @default.
• W2156850323 cites W2323594460 @default.
• W2156850323 cites W237801931 @default.
• W2156850323 cites W2405458061 @default.
• W2156850323 cites W2439120531 @default.
• W2156850323 cites W2737966001 @default.
• W2156850323 cites W3188628058 @default.
• W2156850323 doi "https://doi.org/10.1186/1471-2296-4-7" @default.
• W2156850323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/165418" @default.
• W2156850323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12747810" @default.
• W2156850323 hasPublicationYear "2003" @default.
• W2156850323 type Work @default.
• W2156850323 sameAs 2156850323 @default.
• W2156850323 citedByCount "95" @default.
• W2156850323 countsByYear W21568503232012 @default.
• W2156850323 countsByYear W21568503232013 @default.
• W2156850323 countsByYear W21568503232014 @default.
• W2156850323 countsByYear W21568503232015 @default.
• W2156850323 countsByYear W21568503232016 @default.
• W2156850323 countsByYear W21568503232017 @default.
• W2156850323 countsByYear W21568503232018 @default.
• W2156850323 countsByYear W21568503232019 @default.
• W2156850323 countsByYear W21568503232020 @default.
• W2156850323 countsByYear W21568503232021 @default.
• W2156850323 countsByYear W21568503232022 @default.
• W2156850323 countsByYear W21568503232023 @default.
• W2156850323 crossrefType "journal-article" @default.
• W2156850323 hasAuthorship W2156850323A5011338575 @default.
• W2156850323 hasAuthorship W2156850323A5024592659 @default.
• W2156850323 hasAuthorship W2156850323A5048912647 @default.
• W2156850323 hasBestOaLocation W21568503231 @default.
• W2156850323 hasConcept C118552586 @default.
• W2156850323 hasConcept C126322002 @default.
• W2156850323 hasConcept C134018914 @default.
• W2156850323 hasConcept C139719470 @default.
• W2156850323 hasConcept C142724271 @default.
• W2156850323 hasConcept C159110408 @default.
• W2156850323 hasConcept C162324750 @default.
• W2156850323 hasConcept C204787440 @default.
• W2156850323 hasConcept C27081682 @default.
• W2156850323 hasConcept C2776653193 @default.
• W2156850323 hasConcept C2776867660 @default.
• W2156850323 hasConcept C2777180221 @default.
• W2156850323 hasConcept C2777828372 @default.
• W2156850323 hasConcept C2779177272 @default.
• W2156850323 hasConcept C2779306644 @default.
• W2156850323 hasConcept C2779631380 @default.
• W2156850323 hasConcept C2779951463 @default.
• W2156850323 hasConcept C2780473172 @default.
• W2156850323 hasConcept C555293320 @default.
• W2156850323 hasConcept C558461103 @default.
• W2156850323 hasConcept C71924100 @default.
• W2156850323 hasConceptScore W2156850323C118552586 @default.
• W2156850323 hasConceptScore W2156850323C126322002 @default.
• W2156850323 hasConceptScore W2156850323C134018914 @default.
• W2156850323 hasConceptScore W2156850323C139719470 @default.
• W2156850323 hasConceptScore W2156850323C142724271 @default.
• W2156850323 hasConceptScore W2156850323C159110408 @default.
• W2156850323 hasConceptScore W2156850323C162324750 @default.
• W2156850323 hasConceptScore W2156850323C204787440 @default.
• W2156850323 hasConceptScore W2156850323C27081682 @default.
• W2156850323 hasConceptScore W2156850323C2776653193 @default.
• W2156850323 hasConceptScore W2156850323C2776867660 @default.
• W2156850323 hasConceptScore W2156850323C2777180221 @default.
• W2156850323 hasConceptScore W2156850323C2777828372 @default.
• W2156850323 hasConceptScore W2156850323C2779177272 @default.
• W2156850323 hasConceptScore W2156850323C2779306644 @default.
• W2156850323 hasConceptScore W2156850323C2779631380 @default.
• W2156850323 hasConceptScore W2156850323C2779951463 @default.
• W2156850323 hasConceptScore W2156850323C2780473172 @default.
• W2156850323 hasConceptScore W2156850323C555293320 @default.
• W2156850323 hasConceptScore W2156850323C558461103 @default.
• W2156850323 hasConceptScore W2156850323C71924100 @default.
• W2156850323 hasIssue "1" @default.
• W2156850323 hasLocation W21568503231 @default.
• W2156850323 hasLocation W21568503232 @default.
• W2156850323 hasLocation W21568503233 @default.
• W2156850323 hasLocation W21568503234 @default.
• W2156850323 hasOpenAccess W2156850323 @default.

• next