FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156850730> ?p ?o ?g. }

• W2156850730 endingPage "3079" @default.
• W2156850730 startingPage "3071" @default.
• W2156850730 abstract "Abstract Dietary phytochemicals exhibit chemopreventive potential in vivo through persistent low-dose exposures, whereas mechanistic in vitro studies with these agents generally use a high-dose single treatment. Because the latter approach is not representative of an in vivo steady state, we investigated antitumor activity of curcumin, 3,3′-diindolylmethane (DIM), epigallocatechin gallate (EGCG), genistein, or indole-3-carbinol (I3C) in breast cancer MDA-MB-231 cells, exposed in long-term culture to low concentrations, achievable in vivo. Curcumin and EGCG increased cell doubling time. Curcumin, EGCG, and I3C inhibited clonogenic growth by 55% to 60% and induced 1.5- to 2-fold higher levels of the basal caspase-3/7 activity. No changes in expression of cell cycle–related proteins or survivin were found; however, I3C reduced epidermal growth factor receptor expression, contributing to apoptosis. Because some phytochemicals are shown to inhibit DNA and histone modification, modulation of expression by the agents in a set of genes (cadherin-11, p21Cip1, urokinase-type plasminogen activator, and interleukin-6) was compared with changes induced by inhibitors of DNA methylation or histone deacetylation. The phytochemicals modified protein and/or RNA expression of these genes, with EGCG eliciting the least and DIM the most changes in gene expression. DIM and curcumin decreased cadherin-11 and increased urokinase-type plasminogen activator levels correlated with increased cell motility. Curcumin, DIM, EGCG, and genistein reduced cell sensitivity to radiation-induced DNA damage without affecting DNA repair. This model has revealed that apoptosis and not arrest is likely to be responsible for growth inhibition. It also implicated new molecular targets and activities of the agents under conditions relevant to human exposure. [Mol Cancer Ther 2007;6(11):3071–9]" @default.
• W2156850730 created "2016-06-24" @default.
• W2156850730 creator A5007042251 @default.
• W2156850730 creator A5018340496 @default.
• W2156850730 creator A5053228557 @default.
• W2156850730 creator A5071365469 @default.
• W2156850730 date "2007-11-01" @default.
• W2156850730 modified "2023-10-05" @default.
• W2156850730 title "Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells" @default.
• W2156850730 cites W1520325432 @default.
• W2156850730 cites W1943781072 @default.
• W2156850730 cites W1967670802 @default.
• W2156850730 cites W1972520576 @default.
• W2156850730 cites W1977740695 @default.
• W2156850730 cites W1979805598 @default.
• W2156850730 cites W1986386322 @default.
• W2156850730 cites W1988492454 @default.
• W2156850730 cites W1989646379 @default.
• W2156850730 cites W1992968941 @default.
• W2156850730 cites W2012367306 @default.
• W2156850730 cites W2018652782 @default.
• W2156850730 cites W2041380501 @default.
• W2156850730 cites W2042685741 @default.
• W2156850730 cites W2043681466 @default.
• W2156850730 cites W2043967951 @default.
• W2156850730 cites W2049970571 @default.
• W2156850730 cites W2055378115 @default.
• W2156850730 cites W2055524082 @default.
• W2156850730 cites W2064656637 @default.
• W2156850730 cites W2071447491 @default.
• W2156850730 cites W2079891060 @default.
• W2156850730 cites W2082341926 @default.
• W2156850730 cites W2097127479 @default.
• W2156850730 cites W2098288596 @default.
• W2156850730 cites W2102199428 @default.
• W2156850730 cites W2107987049 @default.
• W2156850730 cites W2110477766 @default.
• W2156850730 cites W2113458915 @default.
• W2156850730 cites W2119331100 @default.
• W2156850730 cites W2124084517 @default.
• W2156850730 cites W2131145936 @default.
• W2156850730 cites W2131176222 @default.
• W2156850730 cites W2135106611 @default.
• W2156850730 cites W2145955453 @default.
• W2156850730 cites W2148033621 @default.
• W2156850730 cites W2155649041 @default.
• W2156850730 cites W2164297850 @default.
• W2156850730 cites W2169058970 @default.
• W2156850730 cites W2318098003 @default.
• W2156850730 cites W248512158 @default.
• W2156850730 doi "https://doi.org/10.1158/1535-7163.mct-07-0117" @default.
• W2156850730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18025290" @default.
• W2156850730 hasPublicationYear "2007" @default.
• W2156850730 type Work @default.
• W2156850730 sameAs 2156850730 @default.
• W2156850730 citedByCount "119" @default.
• W2156850730 countsByYear W21568507302012 @default.
• W2156850730 countsByYear W21568507302013 @default.
• W2156850730 countsByYear W21568507302014 @default.
• W2156850730 countsByYear W21568507302015 @default.
• W2156850730 countsByYear W21568507302016 @default.
• W2156850730 countsByYear W21568507302017 @default.
• W2156850730 countsByYear W21568507302018 @default.
• W2156850730 countsByYear W21568507302019 @default.
• W2156850730 countsByYear W21568507302020 @default.
• W2156850730 countsByYear W21568507302021 @default.
• W2156850730 countsByYear W21568507302022 @default.
• W2156850730 countsByYear W21568507302023 @default.
• W2156850730 crossrefType "journal-article" @default.
• W2156850730 hasAuthorship W2156850730A5007042251 @default.
• W2156850730 hasAuthorship W2156850730A5018340496 @default.
• W2156850730 hasAuthorship W2156850730A5053228557 @default.
• W2156850730 hasAuthorship W2156850730A5071365469 @default.
• W2156850730 hasConcept C134018914 @default.
• W2156850730 hasConcept C153911025 @default.
• W2156850730 hasConcept C190283241 @default.
• W2156850730 hasConcept C2775975398 @default.
• W2156850730 hasConcept C2778250585 @default.
• W2156850730 hasConcept C2778298627 @default.
• W2156850730 hasConcept C2779679481 @default.
• W2156850730 hasConcept C502942594 @default.
• W2156850730 hasConcept C55493867 @default.
• W2156850730 hasConcept C62112901 @default.
• W2156850730 hasConcept C86803240 @default.
• W2156850730 hasConcept C98274493 @default.
• W2156850730 hasConceptScore W2156850730C134018914 @default.
• W2156850730 hasConceptScore W2156850730C153911025 @default.
• W2156850730 hasConceptScore W2156850730C190283241 @default.
• W2156850730 hasConceptScore W2156850730C2775975398 @default.
• W2156850730 hasConceptScore W2156850730C2778250585 @default.
• W2156850730 hasConceptScore W2156850730C2778298627 @default.
• W2156850730 hasConceptScore W2156850730C2779679481 @default.
• W2156850730 hasConceptScore W2156850730C502942594 @default.
• W2156850730 hasConceptScore W2156850730C55493867 @default.
• W2156850730 hasConceptScore W2156850730C62112901 @default.
• W2156850730 hasConceptScore W2156850730C86803240 @default.
• W2156850730 hasConceptScore W2156850730C98274493 @default.
• W2156850730 hasIssue "11" @default.

• next