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• W2156850783 abstract "Background & objectives: Activation of T cells is mediated through two critical signals provided byactivated macrophages. The first signal is triggered when T cell receptor (TCR) binds to the majorhistocompatibility antigen (MHC/Ag) complex. The second signal is the interaction of co-stimulatorymolecules with their respective ligands on T cells for their activation and proliferation. We undertookthis study to observe the modulation in B7.1 (CD80) and B7.2 (CD86) co-stimulatory molecules onMycobacterium tuberculosis infected monocyte derived macrophages (MDM) and their role in Thelper (Th1) cell apoptosis.Methods: M. tuberculosis clinical strains (S7 and S10) and laboratory strains (H37Ra and H37Rv)were used to infect the MDMs. The modulation of apoptosis was assessed by treating T cells withanti-CD3 and anti-CD28 antibodies. The infected MDMs were co-cultured with autologous PPDpulsed T cells to ascertain the role of co-stimulatory molecules during infection.Results: In infected MDMs, all strains on day 1 but only S7 on day 2 showed significant decrease(P<0.05) in B7.1 expression compared to uninfected. The expression levels of B7.2 were also low onday 1 in S7, S10 and H37Ra infected MDMs. The anit-CD3 induced apoptosis in PPD pulsed Tcellsshowed further reduction with anti-CD28 antibodies. However, the modulation observed inB7.1 expression in infected MDMs was not reflected in T cell apoptosis in co-culture experiments.Interpretation & conclusions: Our results confirmed the role of B7.1 in rescuing the activated Tcellsfrom undergoing apoptosis. During infection when the expression of B7.1 is downregulated,other co-stimulatory molecules may take over its crucial role to confer protective immune responseagainst M. tuberculosis." @default.
• W2156850783 created "2016-06-24" @default.
• W2156850783 creator A5038443347 @default.
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• W2156850783 date "2008-04-01" @default.
• W2156850783 modified "2023-09-27" @default.
• W2156850783 title "Expression of co-stimulatory molecules B7.1 & B7.2 on macrophages infected with various strains of Mycobacterium tuberculosis & its influence on T-cell apoptosis." @default.
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• W2156850783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18577795" @default.
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