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- W2156853262 endingPage "256" @default.
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- W2156853262 abstract "LDL cholesterol (LDL-C) is central to the pathogenesis of atherosclerosis and lowering LDL-C is an important component of cardiovascular disease prevention. This article briefly reviews current LDL-C-lowering strategies and then focuses on novel strategies to reduce LDL-C. Lead compounds of the thyromimetic and squalene synthase inhibitor classes were discontinued due to toxicity. Currently, three novel strategies for LDL-C reduction are in clinical development. Hepatic apoB100 production can be reduced with an antisense oligonucleotide (mipomersen), while production of apoB-containing lipoproteins in the gut and liver is reduced by an inhibitor of microsomal triglyceride transfer protein (lomitapide). apoB-containing lipoprotein clearance can also be enhanced by inhibiting PCSK9. Secreted PCSK9 targets LDL receptors for degradation. As PCSK9 levels are upregulated by statin therapy, PCSK9 inhibition may complement statin therapy. Of the multiple strategies to inhibit PCSK9 under development, monoclonal antibodies have progressed furthest in their clinical development." @default.
- W2156853262 created "2016-06-24" @default.
- W2156853262 creator A5033634514 @default.
- W2156853262 creator A5035047137 @default.
- W2156853262 creator A5044425699 @default.
- W2156853262 creator A5078515650 @default.
- W2156853262 date "2013-04-01" @default.
- W2156853262 modified "2023-10-03" @default.
- W2156853262 title "The potential use of monoclonal antibodies and other novel agents as drugs to lower LDL cholesterol" @default.
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