FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156857299> ?p ?o ?g. }

• W2156857299 endingPage "1822" @default.
• W2156857299 startingPage "1811" @default.
• W2156857299 abstract "ABSTRACT Numerous studies have described a strong association between respiratory syncytial virus (RSV) infection in infancy and the development of recurrent wheezing and airway hyperresponsiveness. We evaluated the effect of an anti-RSV neutralizing monoclonal antibody (palivizumab) on different aspects of RSV disease by using a murine model. BALB/c mice were intranasally inoculated with RSV A2. Palivizumab or an isotype-matched control antibody was administered once at 24 h before inoculation, 1 h after inoculation, or 48 h after inoculation. Regardless of the timing of administration, all mice treated with the neutralizing antibody showed significantly decreased RSV loads in bronchoalveolar lavage (BAL) and lung specimens compared with those of infected controls. Pulmonary histopathologic scores, airway obstruction measured by plethysmography, and airway hyperresponsiveness after methacholine challenge were significantly reduced in mice treated with the anti-RSV antibody 24 h before inoculation compared with those for untreated controls. Concentrations of interferon-gamma, interleukin-10, macrophage inflammatory protein 1α, regulated on activation normal T-cell expressed and secreted (RANTES), and eotaxin in BAL fluids were also significantly reduced in mice treated with palivizumab 24 h before inoculation. This study demonstrates that reduced RSV replication was associated with significant modulation of inflammatory and clinical markers of acute disease severity and significant improvement of the long-term pulmonary abnormalities. Studies to determine whether strategies aimed at preventing or reducing RSV replication could decrease the long-term morbidity associated with RSV infection in children should be considered." @default.
• W2156857299 created "2016-06-24" @default.
• W2156857299 creator A5009464778 @default.
• W2156857299 creator A5038778472 @default.
• W2156857299 creator A5046189810 @default.
• W2156857299 creator A5046786963 @default.
• W2156857299 creator A5049592946 @default.
• W2156857299 creator A5051740332 @default.
• W2156857299 creator A5054247751 @default.
• W2156857299 creator A5069122156 @default.
• W2156857299 creator A5069595062 @default.
• W2156857299 creator A5075062830 @default.
• W2156857299 date "2004-05-01" @default.
• W2156857299 modified "2023-09-29" @default.
• W2156857299 title "Anti-Respiratory Syncytial Virus (RSV) Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction, and Airway Hyperresponsiveness in a Murine RSV Model" @default.
• W2156857299 cites W1481591373 @default.
• W2156857299 cites W1642011293 @default.
• W2156857299 cites W1971057004 @default.
• W2156857299 cites W1971823133 @default.
• W2156857299 cites W1975300426 @default.
• W2156857299 cites W1980267456 @default.
• W2156857299 cites W1981503983 @default.
• W2156857299 cites W1987180724 @default.
• W2156857299 cites W1990281734 @default.
• W2156857299 cites W1990559869 @default.
• W2156857299 cites W1993808955 @default.
• W2156857299 cites W2006181104 @default.
• W2156857299 cites W2019706667 @default.
• W2156857299 cites W2027079842 @default.
• W2156857299 cites W2033764561 @default.
• W2156857299 cites W2036023456 @default.
• W2156857299 cites W2044682652 @default.
• W2156857299 cites W2048734600 @default.
• W2156857299 cites W2051861063 @default.
• W2156857299 cites W2058112515 @default.
• W2156857299 cites W2060132446 @default.
• W2156857299 cites W2071350295 @default.
• W2156857299 cites W2072963484 @default.
• W2156857299 cites W2076770315 @default.
• W2156857299 cites W2077290707 @default.
• W2156857299 cites W2078168327 @default.
• W2156857299 cites W2080731454 @default.
• W2156857299 cites W2082457404 @default.
• W2156857299 cites W2087082234 @default.
• W2156857299 cites W2088047510 @default.
• W2156857299 cites W2097386432 @default.
• W2156857299 cites W2097984707 @default.
• W2156857299 cites W2098270374 @default.
• W2156857299 cites W2101292818 @default.
• W2156857299 cites W2104424665 @default.
• W2156857299 cites W2115217734 @default.
• W2156857299 cites W2125164095 @default.
• W2156857299 cites W2128148109 @default.
• W2156857299 cites W2131339985 @default.
• W2156857299 cites W2134224958 @default.
• W2156857299 cites W2136494852 @default.
• W2156857299 cites W2137511411 @default.
• W2156857299 cites W2150757266 @default.
• W2156857299 cites W2151539516 @default.
• W2156857299 cites W2153231621 @default.
• W2156857299 cites W2153537922 @default.
• W2156857299 cites W2154980745 @default.
• W2156857299 cites W2171293480 @default.
• W2156857299 cites W2265593905 @default.
• W2156857299 cites W2312397711 @default.
• W2156857299 cites W2328116798 @default.
• W2156857299 cites W4210256904 @default.
• W2156857299 cites W4292315834 @default.
• W2156857299 doi "https://doi.org/10.1128/aac.48.5.1811-1822.2004" @default.
• W2156857299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/400529" @default.
• W2156857299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15105140" @default.
• W2156857299 hasPublicationYear "2004" @default.
• W2156857299 type Work @default.
• W2156857299 sameAs 2156857299 @default.
• W2156857299 citedByCount "93" @default.
• W2156857299 countsByYear W21568572992012 @default.
• W2156857299 countsByYear W21568572992013 @default.
• W2156857299 countsByYear W21568572992014 @default.
• W2156857299 countsByYear W21568572992015 @default.
• W2156857299 countsByYear W21568572992016 @default.
• W2156857299 countsByYear W21568572992017 @default.
• W2156857299 countsByYear W21568572992018 @default.
• W2156857299 countsByYear W21568572992019 @default.
• W2156857299 countsByYear W21568572992020 @default.
• W2156857299 countsByYear W21568572992023 @default.
• W2156857299 crossrefType "journal-article" @default.
• W2156857299 hasAuthorship W2156857299A5009464778 @default.
• W2156857299 hasAuthorship W2156857299A5038778472 @default.
• W2156857299 hasAuthorship W2156857299A5046189810 @default.
• W2156857299 hasAuthorship W2156857299A5046786963 @default.
• W2156857299 hasAuthorship W2156857299A5049592946 @default.
• W2156857299 hasAuthorship W2156857299A5051740332 @default.
• W2156857299 hasAuthorship W2156857299A5054247751 @default.
• W2156857299 hasAuthorship W2156857299A5069122156 @default.
• W2156857299 hasAuthorship W2156857299A5069595062 @default.
• W2156857299 hasAuthorship W2156857299A5075062830 @default.
• W2156857299 hasBestOaLocation W21568572992 @default.
• W2156857299 hasConcept C126322002 @default.

• next