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- W2156860459 abstract "The plasma concentration of 3-methylhistidine (3MH) has been used in the assessment of nutritional status. Because urinary excretion is the sole route of elimination, and hence a potential determinant of the plasma concentration, 3MH renal handling was examined under different nutritional conditions. Ten obese women consumed a meat-free maintenance energy diet for 4 days before undergoing a 21-day total fast, after which they were assigned into two groups (n = 5) that received 7 days of hypocaloric feeding with 80 g of either milk protein or carbohydrate. 3MH excretion and plasma levels decreased in parallel during fasting and protein refeeding, suggesting that the plasma concentration accurately reflected a decrease of myofibrillar protein turnover, but carbohydrate refeeding was associated with a 31% increase in plasma 3MH (P<.05) despite a concurrent 28% decrease in its excretion (P<.05). This was due to a 41% decrease in 3MH renal clearance (P<.05). Creatinine and urea clearances changed insignificantly in all diet periods. Plasma histidine (HIS) concentrations decreased with fasting and carbohydrate refeeding (P<.05). 3MH clearance was found to be related to the plasma concentration ratio (r=.60, P<.001). Under some circumstances, an altered plasma HIS concentration appears to influence renal 3MH clearance and hence its plasma concentration." @default.
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- W2156860459 date "1990-07-01" @default.
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- W2156860459 title "Nutritional status affects renal 3-methylhistidine handling in humans" @default.
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- W2156860459 doi "https://doi.org/10.1016/0026-0495(90)90111-o" @default.
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