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- W2156860553 abstract "Objectives-To establish betteroperationalcriteria for the diagnosis of Wernicke'sencephalopathy. Current criteriafor diagnosing Wernicke's encephalopathy require thepresenceof threeclinical signs(oculomotor abnormalities, cerebellar dysfunction, andan alteredmentalstate), although ithas oftenbeenreported thatmostpatients do notfilfil allthesecriteria. Methods-Theclinical histories of 28 alcoholics withneurological and neuropsychological assessments anddefinitiveneuropathological diagnoses were examinedtodetermine clinical signs for useinascreening schedule. Operational criteria werethenproposed fordifferentiating patientswith Wernicke's encephalopathy aloneorincombination withKorsakoff's psychosis or hepatic encephalopathy. The new criteria for Wernicke's encephalopathy require twoof thefollowing foursigns; (1)dietary deficiencies, (2)oculomotor abnormalities, (3)cerebellar dysfunction, and(4)either analtered mentalstateormildmemory impairment. Reproducibility andvalidity testing ofthesecriteria wereperformed on 106alcoholics screened froma large necropsy sample. Results-Despite ratervariability with regardtospecific symptoms,withinand betweenraterreliability fordiagnostic classification usingthecriteria retrospectively on patient records was 100%for threeindependent raters. Validity testing showedthatWernicke's encephalopathy wasunderrecognised onlywhenoccurring withhepatic encephalopathy (50%sensitivity). Conclusions-By contrast withcurrent criteria, theproposed operational criteria showthattheantemortemidentification of Wernicke's encephalopathy can be achieved withahighdegree ofspecificity. (Neurol Neurosurg Psychiatry 1997;62:51-60)" @default.
- W2156860553 created "2016-06-24" @default.
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- W2156860553 date "1997-01-01" @default.
- W2156860553 modified "2023-09-27" @default.
- W2156860553 title "Operational criteria fortheclassification of chronic alcoholics: identification ofWemicke's encephalopathy" @default.
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- W2156860553 hasPublicationYear "1997" @default.
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