FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156861981> ?p ?o ?g. }

• W2156861981 abstract "As new multi-target tyrosine kinase inhibitors are emerging in the therapy of various malignancies, our aim was to define the co-expression pattern of receptor-tyrosine-kinase platelet-derived growth factor receptors α and β (PDGFRα/β) in human colorectal cancer. The co-expression pattern of PDGFRα/β was analyzed by RT-PCR in 99 histologically confirmed human colorectal carcinomas and five colorectal cancer cell lines. In addition, immunohistochemical (IHC) staining was applied for confirmation of expression and analysis of receptor tyrosine kinase (RTK) localisation. The colorectal cancer cell lines that were analysed revealed varying expression intensities of PDGFRα and PDGFRβ. The majority of human colorectal cancer specimens revealed a PDGFRα (83%) or PDGFRβ (60%) expression. While PDGFRα showed a predominantly cytoplasmic staining in tumor cells as well as in stromal pericytes, PDGFRβ was restricted to stromal pericytes only. Furthermore, PDGFRα expression significantly correlated with lymph node metastasis (P=0.0082) and advanced UICC stages III/IV (P=0.018) in older patients (P=0.043). PDGFRβ expression only revealed a trend towards lymphatic dissemination (P=0.099). Co-expression of PDGFRα/β occurred in 57% of the colorectal cancer samples, whereas another 29% of the samples depicted mono-expression of PDGFRα or PDGFRβ. Notably, PDGFRα/β expression significantly correlated with lymphatic metastasis (P=0.007) and advanced UICC stages III/IV (P=0.017) in older patients (P=0.03). In summary, our results revealed that PDGFRα/β expression significantly correlates with lymphatic dissemination and therefore encourages application of PDGFRα/β RTK-inhibitors within a combination therapy." @default.
• W2156861981 created "2016-06-24" @default.
• W2156861981 creator A5001554338 @default.
• W2156861981 creator A5004381584 @default.
• W2156861981 creator A5009529288 @default.
• W2156861981 creator A5022970757 @default.
• W2156861981 creator A5030688982 @default.
• W2156861981 creator A5030705786 @default.
• W2156861981 creator A5038131926 @default.
• W2156861981 creator A5040589443 @default.
• W2156861981 creator A5064680394 @default.
• W2156861981 creator A5067876841 @default.
• W2156861981 creator A5073907796 @default.
• W2156861981 creator A5080071751 @default.
• W2156861981 creator A5083168604 @default.
• W2156861981 date "2008-03-01" @default.
• W2156861981 modified "2023-09-30" @default.
• W2156861981 title "PDGFRα/β expression correlates with the metastatic behavior of human colorectal cancer: A possible rationale for a molecular targeting strategy" @default.
• W2156861981 doi "https://doi.org/10.3892/or.19.3.697" @default.
• W2156861981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18288404" @default.
• W2156861981 hasPublicationYear "2008" @default.
• W2156861981 type Work @default.
• W2156861981 sameAs 2156861981 @default.
• W2156861981 citedByCount "23" @default.
• W2156861981 countsByYear W21568619812012 @default.
• W2156861981 countsByYear W21568619812013 @default.
• W2156861981 countsByYear W21568619812014 @default.
• W2156861981 countsByYear W21568619812015 @default.
• W2156861981 countsByYear W21568619812016 @default.
• W2156861981 countsByYear W21568619812017 @default.
• W2156861981 countsByYear W21568619812018 @default.
• W2156861981 countsByYear W21568619812019 @default.
• W2156861981 countsByYear W21568619812020 @default.
• W2156861981 countsByYear W21568619812022 @default.
• W2156861981 crossrefType "journal-article" @default.
• W2156861981 hasAuthorship W2156861981A5001554338 @default.
• W2156861981 hasAuthorship W2156861981A5004381584 @default.
• W2156861981 hasAuthorship W2156861981A5009529288 @default.
• W2156861981 hasAuthorship W2156861981A5022970757 @default.
• W2156861981 hasAuthorship W2156861981A5030688982 @default.
• W2156861981 hasAuthorship W2156861981A5030705786 @default.
• W2156861981 hasAuthorship W2156861981A5038131926 @default.
• W2156861981 hasAuthorship W2156861981A5040589443 @default.
• W2156861981 hasAuthorship W2156861981A5064680394 @default.
• W2156861981 hasAuthorship W2156861981A5067876841 @default.
• W2156861981 hasAuthorship W2156861981A5073907796 @default.
• W2156861981 hasAuthorship W2156861981A5080071751 @default.
• W2156861981 hasAuthorship W2156861981A5083168604 @default.
• W2156861981 hasBestOaLocation W21568619811 @default.
• W2156861981 hasConcept C101544691 @default.
• W2156861981 hasConcept C121608353 @default.
• W2156861981 hasConcept C126322002 @default.
• W2156861981 hasConcept C142724271 @default.
• W2156861981 hasConcept C16930146 @default.
• W2156861981 hasConcept C170493617 @default.
• W2156861981 hasConcept C180361614 @default.
• W2156861981 hasConcept C204232928 @default.
• W2156861981 hasConcept C2775960820 @default.
• W2156861981 hasConcept C2779013556 @default.
• W2156861981 hasConcept C2781018059 @default.
• W2156861981 hasConcept C29537977 @default.
• W2156861981 hasConcept C42362537 @default.
• W2156861981 hasConcept C502942594 @default.
• W2156861981 hasConcept C526805850 @default.
• W2156861981 hasConcept C71924100 @default.
• W2156861981 hasConcept C86803240 @default.
• W2156861981 hasConceptScore W2156861981C101544691 @default.
• W2156861981 hasConceptScore W2156861981C121608353 @default.
• W2156861981 hasConceptScore W2156861981C126322002 @default.
• W2156861981 hasConceptScore W2156861981C142724271 @default.
• W2156861981 hasConceptScore W2156861981C16930146 @default.
• W2156861981 hasConceptScore W2156861981C170493617 @default.
• W2156861981 hasConceptScore W2156861981C180361614 @default.
• W2156861981 hasConceptScore W2156861981C204232928 @default.
• W2156861981 hasConceptScore W2156861981C2775960820 @default.
• W2156861981 hasConceptScore W2156861981C2779013556 @default.
• W2156861981 hasConceptScore W2156861981C2781018059 @default.
• W2156861981 hasConceptScore W2156861981C29537977 @default.
• W2156861981 hasConceptScore W2156861981C42362537 @default.
• W2156861981 hasConceptScore W2156861981C502942594 @default.
• W2156861981 hasConceptScore W2156861981C526805850 @default.
• W2156861981 hasConceptScore W2156861981C71924100 @default.
• W2156861981 hasConceptScore W2156861981C86803240 @default.
• W2156861981 hasLocation W21568619811 @default.
• W2156861981 hasLocation W21568619812 @default.
• W2156861981 hasOpenAccess W2156861981 @default.
• W2156861981 hasPrimaryLocation W21568619811 @default.
• W2156861981 hasRelatedWork W1967789049 @default.
• W2156861981 hasRelatedWork W1975859778 @default.
• W2156861981 hasRelatedWork W2063605511 @default.
• W2156861981 hasRelatedWork W2066018157 @default.
• W2156861981 hasRelatedWork W2107813887 @default.
• W2156861981 hasRelatedWork W2329289908 @default.
• W2156861981 hasRelatedWork W2370561079 @default.
• W2156861981 hasRelatedWork W2979503114 @default.
• W2156861981 hasRelatedWork W3173207637 @default.
• W2156861981 hasRelatedWork W4296046506 @default.
• W2156861981 isParatext "false" @default.
• W2156861981 isRetracted "false" @default.
• W2156861981 magId "2156861981" @default.

• next