FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156864100> ?p ?o ?g. }

• W2156864100 endingPage "7446" @default.
• W2156864100 startingPage "7441" @default.
• W2156864100 abstract "Most studies of tumor instability are PCR-based. PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes. Using a novel PCR-free random cloning/sequencing method, we analyzed 100 kb of total genomic DNA from blood lymphocytes, normal prostate and tumor prostate taken from six individuals. Variations were identified by comparison of the sequence of the cloned fragments with the nr-database in Genbank. After excluding known polymorphisms (by comparison to the NCBI dbSNP), we report a significant over-representation of variants in the tumors: 0.66 variations per kilobase of sequence, compared with the corresponding normal prostates (0.14 variations/kb) or blood (0.09 variations/kb). Extrapolating the observed difference between tumor and normal prostate DNA, we estimate 1.8 million somatic ( de novo ) alterations per tumor cell genome, a much higher frequency than previous measurements obtained by mostly PCR-based methods in other tumor types. Moreover, unlike the normal prostate and blood, most of the tumor variations occur in a specific motif ( P = 0.046), suggesting common etiology. We further report high tumor cell-to-cell heterogeneity. These data have important implications for selecting appropriate technologies for cancer genome projects as well as for understanding prostate cancer progression." @default.
• W2156864100 created "2016-06-24" @default.
• W2156864100 creator A5016446500 @default.
• W2156864100 creator A5021156608 @default.
• W2156864100 creator A5048990711 @default.
• W2156864100 creator A5077120552 @default.
• W2156864100 date "2009-10-01" @default.
• W2156864100 modified "2023-10-06" @default.
• W2156864100 title "PCR-free method detects high frequency of genomic instability in prostate cancer" @default.
• W2156864100 cites W1965573049 @default.
• W2156864100 cites W2023494868 @default.
• W2156864100 cites W2023568503 @default.
• W2156864100 cites W2025183726 @default.
• W2156864100 cites W2043103956 @default.
• W2156864100 cites W2046928699 @default.
• W2156864100 cites W2063728375 @default.
• W2156864100 cites W2069129860 @default.
• W2156864100 cites W2079470725 @default.
• W2156864100 cites W2117570501 @default.
• W2156864100 cites W2118426547 @default.
• W2156864100 cites W2121518362 @default.
• W2156864100 cites W2140882931 @default.
• W2156864100 cites W2145307001 @default.
• W2156864100 cites W2159082261 @default.
• W2156864100 cites W2159322582 @default.
• W2156864100 cites W2164291580 @default.
• W2156864100 cites W4238448376 @default.
• W2156864100 doi "https://doi.org/10.1093/nar/gkp761" @default.
• W2156864100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2794161" @default.
• W2156864100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19797393" @default.
• W2156864100 hasPublicationYear "2009" @default.
• W2156864100 type Work @default.
• W2156864100 sameAs 2156864100 @default.
• W2156864100 citedByCount "7" @default.
• W2156864100 countsByYear W21568641002012 @default.
• W2156864100 countsByYear W21568641002014 @default.
• W2156864100 countsByYear W21568641002017 @default.
• W2156864100 countsByYear W21568641002018 @default.
• W2156864100 countsByYear W21568641002020 @default.
• W2156864100 crossrefType "journal-article" @default.
• W2156864100 hasAuthorship W2156864100A5016446500 @default.
• W2156864100 hasAuthorship W2156864100A5021156608 @default.
• W2156864100 hasAuthorship W2156864100A5048990711 @default.
• W2156864100 hasAuthorship W2156864100A5077120552 @default.
• W2156864100 hasBestOaLocation W21568641001 @default.
• W2156864100 hasConcept C104317684 @default.
• W2156864100 hasConcept C121608353 @default.
• W2156864100 hasConcept C135763542 @default.
• W2156864100 hasConcept C141231307 @default.
• W2156864100 hasConcept C143425029 @default.
• W2156864100 hasConcept C153209595 @default.
• W2156864100 hasConcept C153911025 @default.
• W2156864100 hasConcept C178169997 @default.
• W2156864100 hasConcept C2776235491 @default.
• W2156864100 hasConcept C2780192828 @default.
• W2156864100 hasConcept C35794970 @default.
• W2156864100 hasConcept C502942594 @default.
• W2156864100 hasConcept C51679486 @default.
• W2156864100 hasConcept C54355233 @default.
• W2156864100 hasConcept C552990157 @default.
• W2156864100 hasConcept C70721500 @default.
• W2156864100 hasConcept C86803240 @default.
• W2156864100 hasConceptScore W2156864100C104317684 @default.
• W2156864100 hasConceptScore W2156864100C121608353 @default.
• W2156864100 hasConceptScore W2156864100C135763542 @default.
• W2156864100 hasConceptScore W2156864100C141231307 @default.
• W2156864100 hasConceptScore W2156864100C143425029 @default.
• W2156864100 hasConceptScore W2156864100C153209595 @default.
• W2156864100 hasConceptScore W2156864100C153911025 @default.
• W2156864100 hasConceptScore W2156864100C178169997 @default.
• W2156864100 hasConceptScore W2156864100C2776235491 @default.
• W2156864100 hasConceptScore W2156864100C2780192828 @default.
• W2156864100 hasConceptScore W2156864100C35794970 @default.
• W2156864100 hasConceptScore W2156864100C502942594 @default.
• W2156864100 hasConceptScore W2156864100C51679486 @default.
• W2156864100 hasConceptScore W2156864100C54355233 @default.
• W2156864100 hasConceptScore W2156864100C552990157 @default.
• W2156864100 hasConceptScore W2156864100C70721500 @default.
• W2156864100 hasConceptScore W2156864100C86803240 @default.
• W2156864100 hasIssue "22" @default.
• W2156864100 hasLocation W21568641001 @default.
• W2156864100 hasLocation W21568641002 @default.
• W2156864100 hasLocation W21568641003 @default.
• W2156864100 hasLocation W21568641004 @default.
• W2156864100 hasOpenAccess W2156864100 @default.
• W2156864100 hasPrimaryLocation W21568641001 @default.
• W2156864100 hasRelatedWork W1603543036 @default.
• W2156864100 hasRelatedWork W1980245127 @default.
• W2156864100 hasRelatedWork W1988509800 @default.
• W2156864100 hasRelatedWork W2002128513 @default.
• W2156864100 hasRelatedWork W2063466305 @default.
• W2156864100 hasRelatedWork W2069184423 @default.
• W2156864100 hasRelatedWork W2255506873 @default.
• W2156864100 hasRelatedWork W2400504790 @default.
• W2156864100 hasRelatedWork W2092874662 @default.
• W2156864100 hasRelatedWork W2187207551 @default.
• W2156864100 hasVolume "37" @default.
• W2156864100 isParatext "false" @default.

• next