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- W2156864427 abstract "SPECIFIC AIMSThe goals of this work were to investigate 1) the effects of the anti-psoriatic drug anthralin on mitochondrial function and the activity of individual respiratory chain complexes in living human keratinocytes; and 2) whether anthralin might be acting on mitochondria to induce keratinocyte apoptosis, thus contributing to its therapeutic efficacy in clearing psoriatic plaques.PRINCIPAL FINDINGS1. Anthralin induces disruption of ΔΨm in human keratinocytesAnthralin induced a dose and time-dependent reduction of ΔΨm (measured as the fluorescence intensity ratio of JC-1 red J-aggregates/green monomers) in human keratinocytes (Fig. 1⤻ A). Mitochondria, highlighted by fluorescent JC-1 J-aggregates, appeared swollen, rounded with loss of their filamentous shape, and aggregated around the nucleus after 1 h treatment with anthralin (Fig. 1A⤻ ). Figure 1.Anthralin dissipates mitochondrial membrane potential, induces perinuclear clustering of mitochondria, cytochrome c release, and apoptotic cell death i..." @default.
- W2156864427 created "2016-06-24" @default.
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- W2156864427 date "2005-03-31" @default.
- W2156864427 modified "2023-10-17" @default.
- W2156864427 title "The antipsoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria" @default.
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- W2156864427 doi "https://doi.org/10.1096/fj.04-2664fje" @default.
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