FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156865722> ?p ?o ?g. }

• W2156865722 endingPage "2563" @default.
• W2156865722 startingPage "2555" @default.
• W2156865722 abstract "Abstract Y-family DNA polymerases play a crucial role in translesion DNA synthesis. Here, we have characterized the binding kinetics and conformational dynamics of the Y-family polymerase Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) using single-molecule fluorescence. We find that in the absence of dNTPs, the binary complex shuttles between two different conformations within ∼1 s. These data are consistent with prior crystal structures in which the nucleotide binding site is either occupied by the terminal base pair (preinsertion conformation) or empty following Dpo4 translocation by 1 base pair (insertion conformation). Most interestingly, on dNTP binding, only the insertion conformation is observed and the correct dNTP stabilizes this complex compared with the binary complex, whereas incorrect dNTPs destabilize it. However, if the n+1 template base is complementary to the incoming dNTP, a structure consistent with a misaligned template conformation is observed, in which the template base at the n position loops out. This structure provides evidence for a Dpo4 mutagenesis pathway involving a transient misalignment mechanism." @default.
• W2156865722 created "2016-06-24" @default.
• W2156865722 creator A5026614204 @default.
• W2156865722 creator A5038026572 @default.
• W2156865722 creator A5046352274 @default.
• W2156865722 creator A5066163621 @default.
• W2156865722 date "2013-11-21" @default.
• W2156865722 modified "2023-09-30" @default.
• W2156865722 title "Nucleotide selection by the Y-family DNA polymerase Dpo4 involves template translocation and misalignment" @default.
• W2156865722 cites W1510611530 @default.
• W2156865722 cites W1520835950 @default.
• W2156865722 cites W1969030130 @default.
• W2156865722 cites W1979244293 @default.
• W2156865722 cites W1980745500 @default.
• W2156865722 cites W1986594702 @default.
• W2156865722 cites W2006357154 @default.
• W2156865722 cites W2008233255 @default.
• W2156865722 cites W2009442572 @default.
• W2156865722 cites W2014435144 @default.
• W2156865722 cites W2021665606 @default.
• W2156865722 cites W2023606600 @default.
• W2156865722 cites W2029420481 @default.
• W2156865722 cites W2029481180 @default.
• W2156865722 cites W2030961393 @default.
• W2156865722 cites W2036362320 @default.
• W2156865722 cites W2036894316 @default.
• W2156865722 cites W2041544593 @default.
• W2156865722 cites W2045110889 @default.
• W2156865722 cites W2057508140 @default.
• W2156865722 cites W2065626377 @default.
• W2156865722 cites W2065874951 @default.
• W2156865722 cites W2066790586 @default.
• W2156865722 cites W2067371216 @default.
• W2156865722 cites W2069352337 @default.
• W2156865722 cites W2074566613 @default.
• W2156865722 cites W2077367649 @default.
• W2156865722 cites W2078485114 @default.
• W2156865722 cites W2079064906 @default.
• W2156865722 cites W2079955502 @default.
• W2156865722 cites W2085463974 @default.
• W2156865722 cites W2086790509 @default.
• W2156865722 cites W2087667357 @default.
• W2156865722 cites W2088404436 @default.
• W2156865722 cites W2091162590 @default.
• W2156865722 cites W2093814864 @default.
• W2156865722 cites W2102752109 @default.
• W2156865722 cites W2112301821 @default.
• W2156865722 cites W2132341951 @default.
• W2156865722 cites W2143064529 @default.
• W2156865722 cites W2146859052 @default.
• W2156865722 cites W2154261378 @default.
• W2156865722 cites W2154550802 @default.
• W2156865722 cites W2167858141 @default.
• W2156865722 doi "https://doi.org/10.1093/nar/gkt1149" @default.
• W2156865722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3936744" @default.
• W2156865722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24270793" @default.
• W2156865722 hasPublicationYear "2013" @default.
• W2156865722 type Work @default.
• W2156865722 sameAs 2156865722 @default.
• W2156865722 citedByCount "29" @default.
• W2156865722 countsByYear W21568657222014 @default.
• W2156865722 countsByYear W21568657222015 @default.
• W2156865722 countsByYear W21568657222016 @default.
• W2156865722 countsByYear W21568657222017 @default.
• W2156865722 countsByYear W21568657222018 @default.
• W2156865722 countsByYear W21568657222019 @default.
• W2156865722 countsByYear W21568657222020 @default.
• W2156865722 countsByYear W21568657222021 @default.
• W2156865722 countsByYear W21568657222022 @default.
• W2156865722 countsByYear W21568657222023 @default.
• W2156865722 crossrefType "journal-article" @default.
• W2156865722 hasAuthorship W2156865722A5026614204 @default.
• W2156865722 hasAuthorship W2156865722A5038026572 @default.
• W2156865722 hasAuthorship W2156865722A5046352274 @default.
• W2156865722 hasAuthorship W2156865722A5066163621 @default.
• W2156865722 hasBestOaLocation W21568657221 @default.
• W2156865722 hasConcept C104317684 @default.
• W2156865722 hasConcept C12554922 @default.
• W2156865722 hasConcept C156719811 @default.
• W2156865722 hasConcept C16318435 @default.
• W2156865722 hasConcept C185581394 @default.
• W2156865722 hasConcept C2756471 @default.
• W2156865722 hasConcept C2780631447 @default.
• W2156865722 hasConcept C31254050 @default.
• W2156865722 hasConcept C501734568 @default.
• W2156865722 hasConcept C512185932 @default.
• W2156865722 hasConcept C550995028 @default.
• W2156865722 hasConcept C552990157 @default.
• W2156865722 hasConcept C55493867 @default.
• W2156865722 hasConcept C67705224 @default.
• W2156865722 hasConcept C82381507 @default.
• W2156865722 hasConcept C86803240 @default.
• W2156865722 hasConceptScore W2156865722C104317684 @default.
• W2156865722 hasConceptScore W2156865722C12554922 @default.
• W2156865722 hasConceptScore W2156865722C156719811 @default.
• W2156865722 hasConceptScore W2156865722C16318435 @default.
• W2156865722 hasConceptScore W2156865722C185581394 @default.
• W2156865722 hasConceptScore W2156865722C2756471 @default.

• next