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- W2156866170 abstract "The purinoreceptor, P2X3 is a ligand-gated cation channel activated by extracellular ATP. It has been reported that ATP can be released during inflammation and tissue damage, which in turn may activate P2X 3 receptors to initiate nociceptive signals. However, little is known about the contribu- tion of P2X3 to the dental pain during pulpal inflammation. Therefore, the purpose of this study was to investigate the expression of P2X3 and its colocalization with TRPV1 to understand the mecha- nism of pain transmission through P2X3 in the human dental pulp with double labeling immunofluo- rescence method. In the human dental pulp, intense P2X 3 immunoreactivity was observed throughout the coronal and radicular pulp. Of all P2X3-positive fibers examined, 79.4% coexpressed TRPV1. This result suggests that P2X3 along with TRPV1 may be involved in the transmission of pain and potentiation of noxious stimuli during pulpal inflammation. (J Kor Acad Cons Dent 32(6):514-521, 2007) ABSTRACT" @default.
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- W2156866170 date "2007-01-01" @default.
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- W2156866170 title "Expression of P2X3and its colocalization with trpv1 in the human dental pulp" @default.
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- W2156866170 doi "https://doi.org/10.5395/jkacd.2007.32.6.514" @default.
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