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- W2156867422 abstract "Myelosuppression is the main hematotoxic effect of 6-mercaptopurine (6-MP), which is an antimetabolite chemotherapy drug. Immune hemolytic anemia associated with this drug has not been previously reported.A 67-year-old man with chronic myelomonocytic leukemia presented with anemia 2 weeks after 6-MP therapy had been initiated. Additional tests provided laboratory evidence of hemolysis. When treatment was stopped, the patient's condition and laboratory results showed a progressive improvement.The direct antiglobulin test was positive for IgG. The eluate and the serum were not reactive with panel red cells but reacted with 6-MP-treated red cells, while the normal serum pool was unreactive. The direct antiglobulin test was no longer positive by 20 days after the cessation of 6-MP therapy.This drug, 6-MP, should be added to the list of drugs that have been reported to cause immune hemolytic anemia by means of the so-called hapten mechanism." @default.
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- W2156867422 date "2000-01-01" @default.
- W2156867422 modified "2023-10-17" @default.
- W2156867422 title "Immune hemolytic anemia induced by 6-mercaptopurine" @default.
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- W2156867422 doi "https://doi.org/10.1046/j.1537-2995.2000.40010075.x" @default.
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