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• W2156873141 abstract "Regulation of inflammation is a crucial component of the immune system in response to injury and infection. In otherwise healthy individuals, an initial acute inflammatory response will subside once the injury or infection is eradicated. However, in certain disease states including autoimmune disease and persistent infection, miscommunication between cells of the immune system leads to a chronic inflammatory response, contributing to disease pathology and exacerbating symptoms. A major regulator of inflammation communication at the cellular level is transcription factor (TF) NF-κB. Under normal conditions, NF-κB is bound to an inhibitor in the cytoplasm. In a chronic disease state, NF-κB is overactive and found in the unbound form, resulting in increased production of inflammatory signals. Transcription factor decoys (TFD) are small nucleic acid sequences (~20 base pairs) that mimic the binding site for the TF on the native DNA, but do not encode for any proteins. By binding to the TF in the cytoplasm, TFD have potential to limit excessive immune signaling and inflammatory protein production. Unfortunately, clinical success of TFD has been hampered by a lack of an effective delivery method. Lack of stability and ease of degradation of the TFD require a protective carrier for delivery; however many synthetic carrier systems induce toxicity or an enhanced inflammatory response. In disease states characterized by excessive inflammation, treatment-induced toxicity or immune response is highly undesirable. The Bader lab has previously reported a nanoparticle carrier system based on natural polysaccharides, designed specifically for the treatment of rheumatoid arthritis. The materials used in this system have properties that can be exploited for the additional application of DNA delivery. This thesis will detail the adaptation of polysialic acid-N-trimethyl chitosan nanoparticles to be used as delivery vehicles for an NF-κB TFD treatment in in vitro models of rheumatoid arthritis and cystic fibrosis." @default.
• W2156873141 created "2016-06-24" @default.
• W2156873141 creator A5037384293 @default.
• W2156873141 date "2015-01-01" @default.
• W2156873141 modified "2023-09-27" @default.
• W2156873141 title "Control of Inflammation Using Drug Delivery Strategies in in vitro Models" @default.
• W2156873141 cites W118353332 @default.
• W2156873141 cites W133541103 @default.
• W2156873141 cites W1481565655 @default.
• W2156873141 cites W1519389373 @default.
• W2156873141 cites W1521338784 @default.
• W2156873141 cites W1534776554 @default.
• W2156873141 cites W1543932617 @default.
• W2156873141 cites W1548219170 @default.
• W2156873141 cites W1557965441 @default.
• W2156873141 cites W1569840519 @default.
• W2156873141 cites W1579977115 @default.
• W2156873141 cites W1580639099 @default.
• W2156873141 cites W164146996 @default.
• W2156873141 cites W1670519844 @default.
• W2156873141 cites W1928823895 @default.
• W2156873141 cites W1965407245 @default.
• W2156873141 cites W1967167881 @default.
• W2156873141 cites W1968300654 @default.
• W2156873141 cites W1969872932 @default.
• W2156873141 cites W1970029768 @default.
• W2156873141 cites W1972321346 @default.
• W2156873141 cites W1972674742 @default.
• W2156873141 cites W1973546785 @default.
• W2156873141 cites W1975828910 @default.
• W2156873141 cites W1976301609 @default.
• W2156873141 cites W1976678915 @default.
• W2156873141 cites W1977139178 @default.
• W2156873141 cites W1977487169 @default.
• W2156873141 cites W1977632809 @default.
• W2156873141 cites W1978410646 @default.
• W2156873141 cites W1978417946 @default.
• W2156873141 cites W1979264223 @default.
• W2156873141 cites W1979993551 @default.
• W2156873141 cites W1980296406 @default.
• W2156873141 cites W1982246664 @default.
• W2156873141 cites W1984683661 @default.
• W2156873141 cites W1984993711 @default.
• W2156873141 cites W1985241728 @default.
• W2156873141 cites W1985353690 @default.
• W2156873141 cites W1987968975 @default.
• W2156873141 cites W1988035274 @default.
• W2156873141 cites W1988250258 @default.
• W2156873141 cites W1988853236 @default.
• W2156873141 cites W1988930884 @default.
• W2156873141 cites W1990065831 @default.
• W2156873141 cites W1990369593 @default.
• W2156873141 cites W1991078379 @default.
• W2156873141 cites W1991648564 @default.
• W2156873141 cites W1991968794 @default.
• W2156873141 cites W1992999268 @default.
• W2156873141 cites W1993561446 @default.
• W2156873141 cites W1994207811 @default.
• W2156873141 cites W1995773181 @default.
• W2156873141 cites W1995812631 @default.
• W2156873141 cites W1996471148 @default.
• W2156873141 cites W1996697333 @default.
• W2156873141 cites W1996998905 @default.
• W2156873141 cites W1998821245 @default.
• W2156873141 cites W2000136129 @default.
• W2156873141 cites W2001288430 @default.
• W2156873141 cites W2002454333 @default.
• W2156873141 cites W2004546165 @default.
• W2156873141 cites W2004695394 @default.
• W2156873141 cites W2007151534 @default.
• W2156873141 cites W2009740943 @default.
• W2156873141 cites W2009809742 @default.
• W2156873141 cites W2010058706 @default.
• W2156873141 cites W2010802338 @default.
• W2156873141 cites W2011370547 @default.
• W2156873141 cites W2011732682 @default.
• W2156873141 cites W2013998409 @default.
• W2156873141 cites W2014583580 @default.
• W2156873141 cites W2014760202 @default.
• W2156873141 cites W2015010038 @default.
• W2156873141 cites W2015185599 @default.
• W2156873141 cites W2015394313 @default.
• W2156873141 cites W2019907096 @default.
• W2156873141 cites W2021084750 @default.
• W2156873141 cites W2022513120 @default.
• W2156873141 cites W2024966103 @default.
• W2156873141 cites W2028014480 @default.
• W2156873141 cites W2028151653 @default.
• W2156873141 cites W2028735371 @default.
• W2156873141 cites W2029366081 @default.
• W2156873141 cites W2029430817 @default.
• W2156873141 cites W2030193124 @default.
• W2156873141 cites W2030855909 @default.
• W2156873141 cites W2031215262 @default.
• W2156873141 cites W2031870438 @default.
• W2156873141 cites W2032105230 @default.
• W2156873141 cites W2033996435 @default.
• W2156873141 cites W2034295073 @default.
• W2156873141 cites W2034421123 @default.
• W2156873141 cites W2035059218 @default.

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