FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156875759> ?p ?o ?g. }

• W2156875759 endingPage "416" @default.
• W2156875759 startingPage "408" @default.
• W2156875759 abstract "Obesity frequently leads to insulin resistance and the development of hepatic steatosis. To characterize the molecular changes that promote hepatic steatosis, transcriptomics, proteomics, and metabolomics technologies were applied to liver samples from C57BL/6J mice obtained from two independent intervention trials. After 12 wk of high-fat feeding the animals became obese, hyperglycemic, and insulin resistant, had elevated levels of blood cholesterol and VLDL, and developed hepatic steatosis. Nutrigenomic analysis revealed alterations of key metabolites and enzyme transcript levels of hepatic one-carbon metabolism and related pathways. The hepatic oxidative capacity and the lipid milieu were significantly altered, which may play a key role in the development of insulin resistance. Additionally, high choline levels were observed after the high-fat diet. Previous studies have linked choline levels with insulin resistance and hepatic steatosis in conjunction with changes of certain metabolites and enzyme levels of one-carbon metabolism. The present results suggest that the coupling of high levels of choline and low levels of methionine plays an important role in the development of insulin resistance and liver steatosis. In conclusion, the complexities of the alterations induced by high-fat feeding are multifactorial, indicating that the interplay between several metabolic pathways is responsible for the pathological consequences." @default.
• W2156875759 created "2016-06-24" @default.
• W2156875759 creator A5000342933 @default.
• W2156875759 creator A5003874766 @default.
• W2156875759 creator A5009972485 @default.
• W2156875759 creator A5021067384 @default.
• W2156875759 creator A5030961072 @default.
• W2156875759 creator A5039971652 @default.
• W2156875759 creator A5053104845 @default.
• W2156875759 creator A5054720911 @default.
• W2156875759 creator A5057449920 @default.
• W2156875759 creator A5060417803 @default.
• W2156875759 creator A5061497248 @default.
• W2156875759 creator A5063674598 @default.
• W2156875759 creator A5073985049 @default.
• W2156875759 creator A5075750072 @default.
• W2156875759 creator A5087940421 @default.
• W2156875759 creator A5088503440 @default.
• W2156875759 date "2011-04-01" @default.
• W2156875759 modified "2023-10-17" @default.
• W2156875759 title "Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention" @default.
• W2156875759 cites W1534360145 @default.
• W2156875759 cites W1558552946 @default.
• W2156875759 cites W1874317773 @default.
• W2156875759 cites W1964895626 @default.
• W2156875759 cites W1970594207 @default.
• W2156875759 cites W1973614663 @default.
• W2156875759 cites W1980711504 @default.
• W2156875759 cites W1991091089 @default.
• W2156875759 cites W1991401793 @default.
• W2156875759 cites W1998323589 @default.
• W2156875759 cites W2014468331 @default.
• W2156875759 cites W2025274735 @default.
• W2156875759 cites W2034086375 @default.
• W2156875759 cites W2041588833 @default.
• W2156875759 cites W2046303225 @default.
• W2156875759 cites W2051256772 @default.
• W2156875759 cites W2052695206 @default.
• W2156875759 cites W2054016219 @default.
• W2156875759 cites W2056277685 @default.
• W2156875759 cites W2060252363 @default.
• W2156875759 cites W2066473815 @default.
• W2156875759 cites W2066561101 @default.
• W2156875759 cites W2068076902 @default.
• W2156875759 cites W2068793226 @default.
• W2156875759 cites W2081098333 @default.
• W2156875759 cites W2082842602 @default.
• W2156875759 cites W2087968524 @default.
• W2156875759 cites W2093824918 @default.
• W2156875759 cites W2096452690 @default.
• W2156875759 cites W2098111353 @default.
• W2156875759 cites W2102785858 @default.
• W2156875759 cites W2120172040 @default.
• W2156875759 cites W2120231978 @default.
• W2156875759 cites W2124850376 @default.
• W2156875759 cites W2125720510 @default.
• W2156875759 cites W2128599926 @default.
• W2156875759 cites W2135827569 @default.
• W2156875759 cites W2138485536 @default.
• W2156875759 cites W2139464173 @default.
• W2156875759 cites W2140976344 @default.
• W2156875759 cites W2143221342 @default.
• W2156875759 cites W2151718403 @default.
• W2156875759 cites W2160697532 @default.
• W2156875759 cites W2164509237 @default.
• W2156875759 cites W2170148526 @default.
• W2156875759 cites W3001763642 @default.
• W2156875759 cites W4238497443 @default.
• W2156875759 cites W4296926797 @default.
• W2156875759 doi "https://doi.org/10.1152/physiolgenomics.00179.2010" @default.
• W2156875759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21303933" @default.
• W2156875759 hasPublicationYear "2011" @default.
• W2156875759 type Work @default.
• W2156875759 sameAs 2156875759 @default.
• W2156875759 citedByCount "65" @default.
• W2156875759 countsByYear W21568757592012 @default.
• W2156875759 countsByYear W21568757592013 @default.
• W2156875759 countsByYear W21568757592014 @default.
• W2156875759 countsByYear W21568757592015 @default.
• W2156875759 countsByYear W21568757592016 @default.
• W2156875759 countsByYear W21568757592017 @default.
• W2156875759 countsByYear W21568757592018 @default.
• W2156875759 countsByYear W21568757592019 @default.
• W2156875759 countsByYear W21568757592020 @default.
• W2156875759 countsByYear W21568757592021 @default.
• W2156875759 countsByYear W21568757592022 @default.
• W2156875759 crossrefType "journal-article" @default.
• W2156875759 hasAuthorship W2156875759A5000342933 @default.
• W2156875759 hasAuthorship W2156875759A5003874766 @default.
• W2156875759 hasAuthorship W2156875759A5009972485 @default.
• W2156875759 hasAuthorship W2156875759A5021067384 @default.
• W2156875759 hasAuthorship W2156875759A5030961072 @default.
• W2156875759 hasAuthorship W2156875759A5039971652 @default.
• W2156875759 hasAuthorship W2156875759A5053104845 @default.
• W2156875759 hasAuthorship W2156875759A5054720911 @default.
• W2156875759 hasAuthorship W2156875759A5057449920 @default.
• W2156875759 hasAuthorship W2156875759A5060417803 @default.
• W2156875759 hasAuthorship W2156875759A5061497248 @default.

• next