FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156875971> ?p ?o ?g. }

• W2156875971 abstract "Abstract Background Leakage of water and ions and soluble proteins from muscle cells occurs during prolonged exercise due to ischemia causing muscle damage. Also post mortem anoxia during conversion of muscle to meat is marked by loss of water and soluble components from the muscle cell. There is considerable variation in the water holding capacity of meat affecting economy of meat production. Water holding capacity depends on numerous genetic and environmental factors relevant to structural and biochemical muscle fibre properties a well as ante and post slaughter metabolic processes. Results Expression microarray analysis of M. longissimus dorsi RNAs of 74 F2 animals of a resource population showed 1,279 transcripts with trait correlated expression to water holding capacity. Negatively correlated transcripts were enriched in functional categories and pathways like extracellular matrix receptor interaction and calcium signalling. Transcripts with positive correlation dominantly represented biochemical processes including oxidative phosphorylation, mitochondrial pathways, as well as transporter activity. A linkage analysis of abundance of trait correlated transcripts revealed 897 expression QTL (eQTL) with 104 eQTL coinciding with QTL regions for water holding capacity; 96 transcripts had trans acting and 8 had cis acting regulation. Conclusion The complex relationships between biological processes taking place in live skeletal muscle and meat quality are driven on the one hand by the energy reserves and their utilisation in the muscle and on the other hand by the muscle structure itself and calcium signalling. Holistic expression profiling was integrated with QTL analysis for the trait of interest and for gene expression levels for creation of a priority list of genes out of the orchestra of genes of biological networks relevant to the liability to develop elevated drip loss." @default.
• W2156875971 created "2016-06-24" @default.
• W2156875971 creator A5000638463 @default.
• W2156875971 creator A5022379448 @default.
• W2156875971 creator A5035157068 @default.
• W2156875971 creator A5035774823 @default.
• W2156875971 creator A5040221274 @default.
• W2156875971 creator A5046860625 @default.
• W2156875971 creator A5064525956 @default.
• W2156875971 creator A5074246919 @default.
• W2156875971 creator A5081222111 @default.
• W2156875971 date "2008-07-31" @default.
• W2156875971 modified "2023-10-06" @default.
• W2156875971 title "Trait correlated expression combined with expression QTL analysis reveals biological pathways and candidate genes affecting water holding capacity of muscle" @default.
• W2156875971 cites W1510172024 @default.
• W2156875971 cites W1524233086 @default.
• W2156875971 cites W1556472699 @default.
• W2156875971 cites W1584781794 @default.
• W2156875971 cites W1605784620 @default.
• W2156875971 cites W1833799802 @default.
• W2156875971 cites W1910080850 @default.
• W2156875971 cites W1964895626 @default.
• W2156875971 cites W1966432036 @default.
• W2156875971 cites W1976741643 @default.
• W2156875971 cites W1978835916 @default.
• W2156875971 cites W1980840962 @default.
• W2156875971 cites W1980862193 @default.
• W2156875971 cites W1981696397 @default.
• W2156875971 cites W1982398730 @default.
• W2156875971 cites W1985871101 @default.
• W2156875971 cites W1990747492 @default.
• W2156875971 cites W2000703483 @default.
• W2156875971 cites W2001366562 @default.
• W2156875971 cites W2003872525 @default.
• W2156875971 cites W2010747467 @default.
• W2156875971 cites W2014292884 @default.
• W2156875971 cites W2014509525 @default.
• W2156875971 cites W2020461377 @default.
• W2156875971 cites W2026609789 @default.
• W2156875971 cites W2027380968 @default.
• W2156875971 cites W2029231027 @default.
• W2156875971 cites W2041959263 @default.
• W2156875971 cites W2042151547 @default.
• W2156875971 cites W2046129276 @default.
• W2156875971 cites W2048097238 @default.
• W2156875971 cites W2059880723 @default.
• W2156875971 cites W2061837746 @default.
• W2156875971 cites W2066784362 @default.
• W2156875971 cites W2079981707 @default.
• W2156875971 cites W2081978814 @default.
• W2156875971 cites W2088465116 @default.
• W2156875971 cites W2093072493 @default.
• W2156875971 cites W2096771687 @default.
• W2156875971 cites W2103017472 @default.
• W2156875971 cites W2103665862 @default.
• W2156875971 cites W2106988040 @default.
• W2156875971 cites W2107141940 @default.
• W2156875971 cites W2108908271 @default.
• W2156875971 cites W2114729479 @default.
• W2156875971 cites W2116265489 @default.
• W2156875971 cites W2118151975 @default.
• W2156875971 cites W2118308505 @default.
• W2156875971 cites W2118674424 @default.
• W2156875971 cites W2125860227 @default.
• W2156875971 cites W2126320556 @default.
• W2156875971 cites W2135458301 @default.
• W2156875971 cites W2135513748 @default.
• W2156875971 cites W2141826410 @default.
• W2156875971 cites W2145747197 @default.
• W2156875971 cites W2148489676 @default.
• W2156875971 cites W2151782652 @default.
• W2156875971 cites W2155925227 @default.
• W2156875971 cites W2162871532 @default.
• W2156875971 cites W2166735118 @default.
• W2156875971 cites W2167685940 @default.
• W2156875971 cites W2169269592 @default.
• W2156875971 cites W2257040781 @default.
• W2156875971 cites W4238092255 @default.
• W2156875971 cites W4239715355 @default.
• W2156875971 cites W4249273120 @default.
• W2156875971 cites W4294216483 @default.
• W2156875971 doi "https://doi.org/10.1186/1471-2164-9-367" @default.
• W2156875971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2529315" @default.
• W2156875971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18671879" @default.
• W2156875971 hasPublicationYear "2008" @default.
• W2156875971 type Work @default.
• W2156875971 sameAs 2156875971 @default.
• W2156875971 citedByCount "82" @default.
• W2156875971 countsByYear W21568759712012 @default.
• W2156875971 countsByYear W21568759712013 @default.
• W2156875971 countsByYear W21568759712014 @default.
• W2156875971 countsByYear W21568759712015 @default.
• W2156875971 countsByYear W21568759712016 @default.
• W2156875971 countsByYear W21568759712017 @default.
• W2156875971 countsByYear W21568759712018 @default.
• W2156875971 countsByYear W21568759712019 @default.
• W2156875971 countsByYear W21568759712020 @default.
• W2156875971 countsByYear W21568759712021 @default.
• W2156875971 countsByYear W21568759712022 @default.
• W2156875971 countsByYear W21568759712023 @default.

• next