FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156877933> ?p ?o ?g. }

• W2156877933 endingPage "196" @default.
• W2156877933 startingPage "190" @default.
• W2156877933 abstract "Fluorescence image analysis of the calcium sensitive dye Indo-1 was used to characterize platelet-activating factor (PAF)-induced calcium mobilization in hepatic macrophages and endothelial cells. PAF, but not lyso-PAF, an inactive analog, induced a rapid and transient increase in intracellular levels of calcium that appeared to depend on the presence of extracellular calcium. In both macrophages and endothelial cells, these effects were dose dependent, reaching maximal levels with 10 nM PAF. However, the kinetics of the calcium response to PAF in macrophages and endothelial cells was distinct. The endothelial cells responded more rapidly to PAF than the macrophages (within 1 min vs. 2-3 min, respectively) and displayed longer recovery periods (4 min vs. > 10 min, respectively). In contrast, the magnitude of the response to PAF was greater in the macrophages. In both cell types, triazolam and alprazolam, two PAF antagonists, and the calcium channel blocker verapamil inhibited PAF-induced calcium mobilization. PAF also stimulated superoxide anion production alone and in combination with the macrophage activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in both cell types. Macrophages produced more of this reactive oxygen intermediate in response to PAF and TPA than endothelial cells. Interestingly, in the absence of extracellular calcium or when verapamil was added to the cultures, superoxide anion production by the macrophages, but not the endothelial cells, was significantly reduced. These results demonstrate that, although hepatic macrophages and endothelial cells mobilize calcium in response to PAF, the characteristics of the response in each cell type are different. These differences may underlie, at least in part, distinct functional responses of the cells to PAF." @default.
• W2156877933 created "2016-06-24" @default.
• W2156877933 creator A5061403639 @default.
• W2156877933 creator A5074461596 @default.
• W2156877933 creator A5081341006 @default.
• W2156877933 date "1993-02-01" @default.
• W2156877933 modified "2023-10-09" @default.
• W2156877933 title "Platelet-activating factor–induced calcium mobilization and oxidative metabolism in hepatic macrophages and endothelial cells" @default.
• W2156877933 cites W147290306 @default.
• W2156877933 cites W1517205234 @default.
• W2156877933 cites W1562515718 @default.
• W2156877933 cites W1592028829 @default.
• W2156877933 cites W1605242131 @default.
• W2156877933 cites W1661850314 @default.
• W2156877933 cites W1893528652 @default.
• W2156877933 cites W1895456593 @default.
• W2156877933 cites W1940786296 @default.
• W2156877933 cites W1962129274 @default.
• W2156877933 cites W1963744047 @default.
• W2156877933 cites W1972802318 @default.
• W2156877933 cites W1973031033 @default.
• W2156877933 cites W1978134137 @default.
• W2156877933 cites W1979140647 @default.
• W2156877933 cites W1979374866 @default.
• W2156877933 cites W1979788207 @default.
• W2156877933 cites W1986092783 @default.
• W2156877933 cites W1989837742 @default.
• W2156877933 cites W1990620192 @default.
• W2156877933 cites W2000296593 @default.
• W2156877933 cites W2016681598 @default.
• W2156877933 cites W2018485379 @default.
• W2156877933 cites W2033899018 @default.
• W2156877933 cites W2034741371 @default.
• W2156877933 cites W2036979418 @default.
• W2156877933 cites W2040864606 @default.
• W2156877933 cites W2041358637 @default.
• W2156877933 cites W2047112694 @default.
• W2156877933 cites W2049116365 @default.
• W2156877933 cites W2051560769 @default.
• W2156877933 cites W2055739022 @default.
• W2156877933 cites W2088968844 @default.
• W2156877933 cites W2094435668 @default.
• W2156877933 cites W2095709462 @default.
• W2156877933 cites W2121159533 @default.
• W2156877933 cites W2134674910 @default.
• W2156877933 cites W2141260882 @default.
• W2156877933 cites W2166376385 @default.
• W2156877933 cites W2184562399 @default.
• W2156877933 cites W2256949862 @default.
• W2156877933 cites W2395692432 @default.
• W2156877933 cites W2399255317 @default.
• W2156877933 cites W2419575807 @default.
• W2156877933 cites W82116684 @default.
• W2156877933 doi "https://doi.org/10.1002/jlb.53.2.190" @default.
• W2156877933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8383168" @default.
• W2156877933 hasPublicationYear "1993" @default.
• W2156877933 type Work @default.
• W2156877933 sameAs 2156877933 @default.
• W2156877933 citedByCount "22" @default.
• W2156877933 countsByYear W21568779332017 @default.
• W2156877933 countsByYear W21568779332018 @default.
• W2156877933 crossrefType "journal-article" @default.
• W2156877933 hasAuthorship W2156877933A5061403639 @default.
• W2156877933 hasAuthorship W2156877933A5074461596 @default.
• W2156877933 hasAuthorship W2156877933A5081341006 @default.
• W2156877933 hasConcept C123012128 @default.
• W2156877933 hasConcept C126322002 @default.
• W2156877933 hasConcept C134018914 @default.
• W2156877933 hasConcept C181080969 @default.
• W2156877933 hasConcept C181199279 @default.
• W2156877933 hasConcept C202751555 @default.
• W2156877933 hasConcept C2776992346 @default.
• W2156877933 hasConcept C2777022698 @default.
• W2156877933 hasConcept C2779020240 @default.
• W2156877933 hasConcept C2780795997 @default.
• W2156877933 hasConcept C28406088 @default.
• W2156877933 hasConcept C519063684 @default.
• W2156877933 hasConcept C55493867 @default.
• W2156877933 hasConcept C71924100 @default.
• W2156877933 hasConcept C86803240 @default.
• W2156877933 hasConceptScore W2156877933C123012128 @default.
• W2156877933 hasConceptScore W2156877933C126322002 @default.
• W2156877933 hasConceptScore W2156877933C134018914 @default.
• W2156877933 hasConceptScore W2156877933C181080969 @default.
• W2156877933 hasConceptScore W2156877933C181199279 @default.
• W2156877933 hasConceptScore W2156877933C202751555 @default.
• W2156877933 hasConceptScore W2156877933C2776992346 @default.
• W2156877933 hasConceptScore W2156877933C2777022698 @default.
• W2156877933 hasConceptScore W2156877933C2779020240 @default.
• W2156877933 hasConceptScore W2156877933C2780795997 @default.
• W2156877933 hasConceptScore W2156877933C28406088 @default.
• W2156877933 hasConceptScore W2156877933C519063684 @default.
• W2156877933 hasConceptScore W2156877933C55493867 @default.
• W2156877933 hasConceptScore W2156877933C71924100 @default.
• W2156877933 hasConceptScore W2156877933C86803240 @default.
• W2156877933 hasIssue "2" @default.
• W2156877933 hasLocation W21568779331 @default.
• W2156877933 hasLocation W21568779332 @default.

• next