FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156879228> ?p ?o ?g. }

• W2156879228 endingPage "4684" @default.
• W2156879228 startingPage "4665" @default.
• W2156879228 abstract "ABSTRACT We previously demonstrated that mutation of the staphylococcal accessory regulator ( sarA ) in a clinical isolate of Staphylococcus aureus (UAMS-1) results in an impaired capacity to form a biofilm in vitro (K. E. Beenken, J. S. Blevins, and M. S. Smeltzer, Infect. Immun. 71:4206-4211, 2003). In this report, we used a murine model of catheter-based biofilm formation to demonstrate that a UAMS-1 sarA mutant also has a reduced capacity to form a biofilm in vivo. Surprisingly, mutation of the UAMS-1 ica locus had little impact on biofilm formation in vitro or in vivo. In an effort to identify additional loci that might be relevant to biofilm formation and/or the adaptive response required for persistence of S. aureus within a biofilm, we isolated total cellular RNA from UAMS-1 harvested from a biofilm grown in a flow cell and compared the transcriptional profile of this RNA to RNA isolated from both exponential- and stationary-phase planktonic cultures. Comparisons were done using a custom-made Affymetrix GeneChip representing the genomic complement of six strains of S. aureus (COL, N315, Mu50, NCTC 8325, EMRSA-16 [strain 252], and MSSA-476). The results confirm that the sessile lifestyle associated with persistence within a biofilm is distinct by comparison to the lifestyles of both the exponential and postexponential phases of planktonic culture. Indeed, we identified 48 genes in which expression was induced at least twofold in biofilms over expression under both planktonic conditions. Similarly, we identified 84 genes in which expression was repressed by a factor of at least 2 compared to expression under both planktonic conditions. A primary theme that emerged from the analysis of these genes is that persistence within a biofilm requires an adaptive response that limits the deleterious effects of the reduced pH associated with anaerobic growth conditions." @default.
• W2156879228 created "2016-06-24" @default.
• W2156879228 creator A5016311404 @default.
• W2156879228 creator A5028765861 @default.
• W2156879228 creator A5041244009 @default.
• W2156879228 creator A5042251265 @default.
• W2156879228 creator A5056534291 @default.
• W2156879228 creator A5065739283 @default.
• W2156879228 creator A5075031124 @default.
• W2156879228 creator A5076939588 @default.
• W2156879228 date "2004-07-15" @default.
• W2156879228 modified "2023-10-12" @default.
• W2156879228 title "Global Gene Expression in <i>Staphylococcus aureus</i> Biofilms" @default.
• W2156879228 cites W1573717529 @default.
• W2156879228 cites W1599640402 @default.
• W2156879228 cites W1623295381 @default.
• W2156879228 cites W1680521456 @default.
• W2156879228 cites W1779034727 @default.
• W2156879228 cites W1827553092 @default.
• W2156879228 cites W1928804885 @default.
• W2156879228 cites W1979652462 @default.
• W2156879228 cites W1982777646 @default.
• W2156879228 cites W1986625081 @default.
• W2156879228 cites W1988676524 @default.
• W2156879228 cites W1991292439 @default.
• W2156879228 cites W1997287919 @default.
• W2156879228 cites W2002410531 @default.
• W2156879228 cites W2004614746 @default.
• W2156879228 cites W2004787404 @default.
• W2156879228 cites W2008768590 @default.
• W2156879228 cites W2009783805 @default.
• W2156879228 cites W2015509108 @default.
• W2156879228 cites W2019191266 @default.
• W2156879228 cites W2023506146 @default.
• W2156879228 cites W2024937891 @default.
• W2156879228 cites W2035890664 @default.
• W2156879228 cites W2036534864 @default.
• W2156879228 cites W2037872675 @default.
• W2156879228 cites W2037918377 @default.
• W2156879228 cites W2040823934 @default.
• W2156879228 cites W2043082319 @default.
• W2156879228 cites W2044726291 @default.
• W2156879228 cites W2046726533 @default.
• W2156879228 cites W2048346532 @default.
• W2156879228 cites W2051465661 @default.
• W2156879228 cites W2055294982 @default.
• W2156879228 cites W2058529626 @default.
• W2156879228 cites W2078606044 @default.
• W2156879228 cites W2098000490 @default.
• W2156879228 cites W2099911577 @default.
• W2156879228 cites W2100092533 @default.
• W2156879228 cites W2102360445 @default.
• W2156879228 cites W2103152340 @default.
• W2156879228 cites W2103688851 @default.
• W2156879228 cites W2108649186 @default.
• W2156879228 cites W2109399675 @default.
• W2156879228 cites W2111154143 @default.
• W2156879228 cites W2118021257 @default.
• W2156879228 cites W2120641113 @default.
• W2156879228 cites W2121052053 @default.
• W2156879228 cites W2121897239 @default.
• W2156879228 cites W2122020611 @default.
• W2156879228 cites W2122792108 @default.
• W2156879228 cites W2125258437 @default.
• W2156879228 cites W2125603952 @default.
• W2156879228 cites W2129964609 @default.
• W2156879228 cites W2131237419 @default.
• W2156879228 cites W2132114933 @default.
• W2156879228 cites W2134305267 @default.
• W2156879228 cites W2135385444 @default.
• W2156879228 cites W2139191979 @default.
• W2156879228 cites W2145684516 @default.
• W2156879228 cites W2147390657 @default.
• W2156879228 cites W2154384223 @default.
• W2156879228 cites W2155419526 @default.
• W2156879228 cites W2156788471 @default.
• W2156879228 cites W2158752477 @default.
• W2156879228 cites W2158978167 @default.
• W2156879228 cites W2163589759 @default.
• W2156879228 cites W2166416963 @default.
• W2156879228 cites W2167476908 @default.
• W2156879228 cites W2167665502 @default.
• W2156879228 cites W2168502776 @default.
• W2156879228 cites W2169674958 @default.
• W2156879228 cites W2170113031 @default.
• W2156879228 cites W2176472482 @default.
• W2156879228 cites W244974531 @default.
• W2156879228 cites W4245276795 @default.
• W2156879228 doi "https://doi.org/10.1128/jb.186.14.4665-4684.2004" @default.
• W2156879228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/438561" @default.
• W2156879228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15231800" @default.
• W2156879228 hasPublicationYear "2004" @default.
• W2156879228 type Work @default.
• W2156879228 sameAs 2156879228 @default.
• W2156879228 citedByCount "544" @default.
• W2156879228 countsByYear W21568792282012 @default.
• W2156879228 countsByYear W21568792282013 @default.
• W2156879228 countsByYear W21568792282014 @default.

• next