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• W2156894584 abstract "IGF-I regulates pituitaryand gonadal functions, and is pivotal for sexual development and fertility in mammalian species. To better understand the function of autocrine IGF-I in Sertoli cell physiology, we established a system for Cre-mediated conditional inactivation of the IGF-I receptor (IGF-IR) in cultured Sertoli cells. We show here that loss of IGF-IR decreased the number of viable Sertoli cells as a consequence of diminished Sertoli cell proliferation and increased Sertoli cell death. Furthermore, the lack of IGF-IR altered the morphology of cultured Sertoli cells and decreased lactate and transferrin secretions. Collectively, our data indicate that autocrine IGF-I contributes significantly to Sertoli cell homeostasis. The described in vitro system for loss-of-function analysis of the IGF-IR can be readily transposed to study the role of other intratesticular growth factors involved in spermatogenesis." @default.
• W2156894584 created "2016-06-24" @default.
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• W2156894584 date "2007-09-01" @default.
• W2156894584 modified "2023-10-17" @default.
• W2156894584 title "Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I" @default.
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• W2156894584 doi "https://doi.org/10.1677/joe-07-0258" @default.
• W2156894584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17761895" @default.
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