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- W2156899080 abstract "Chronic immunosuppression is a known risk factor for tuberculosis. Our aim was to reach a consensus on screening and prevention of tuberculosis in patients with immune mediated inflammatory diseases who are candidates to biologic therapy. Critical appraisal of the literature and expert opinion on immunosuppressive therapies and risk of tuberculosis. The currently recommended method for screening is the tuberculin skin test and the interferon gamma assay, after exclusion of active tuberculosis. Positively screened patients should be treated for latent tuberculosis infection. Patients may start biological therapy after 1–2 months, as long as they are strictly adhering to and tolerating their preventive regimen. A imunossupressão crónica é um reconhecido factor de risco para a tuberculose. O nosso objectivo foi o de obter um consenso para o rastreio e prevenção da tuberculose em portadores de doenças inflamatórias imunomediadas candidatos a terapêutica biológica. Revisão crítica da literatura e opinião de peritos acerca das terapêuticas imunossupressoras e risco de tuberculose. O método actualmente recomendado para o rastreio é o teste cutâneo da tuberculina e o doseamento do interferão gama, após exclusão da tuberculose activa. Doentes com rastreio positivo devem receber tratamento para a tuberculose latente. Estes doentes podem iniciar a terapêutica biológica após 1 a 2 meses, desde que a sua adesão seja rigorosa e apresentem boa tolerância à terapêutica profilática." @default.
- W2156899080 created "2016-06-24" @default.
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- W2156899080 date "2012-11-01" @default.
- W2156899080 modified "2023-09-23" @default.
- W2156899080 title "Position paper on tuberculosis screening in patients with immune mediated inflammatory diseases who are candidates for biological therapy" @default.
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- W2156899080 doi "https://doi.org/10.1016/j.jpg.2012.09.004" @default.
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