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• W2156899450 abstract "We recently demonstrated direct evidence of increased monoamine oxidase (MAO) activity in the brain of a simian immunodeficiency virus (SIV) model of human immunodeficiency virus (HIV)-associated central nervous system (CNS) disease, consistent with previously reported dopamine deficits in both SIV and HIV infection. In this study, we explored potential mechanisms behind this elevated activity. MAO B messenger RNA was highest in macaques with the most severe SIV-associated CNS lesions and was positively correlated with levels of CD68 and GFAP transcripts in the striatum. MAO B messenger RNA also correlated with viral loads in the CNS of SIV-infected macaques and with oxidative stress. Furthermore, in humans, striatal MAO activity was elevated in individuals with HIV encephalitis, compared with activity in HIV-seronegative controls. These data suggest that the neuroinflammation and oxidative stress caused by SIV infection in the CNS may provide the impetus for increased transcription of MAO B and that MAO, and more broadly, oxidative stress, have significant potential as therapeutic targets in CNS disease due to HIV." @default.
• W2156899450 created "2016-06-24" @default.
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• W2156899450 date "2014-03-31" @default.
• W2156899450 modified "2023-10-16" @default.
• W2156899450 title "Elevated Brain Monoamine Oxidase Activity in SIV- and HIV-associated Neurological Disease" @default.
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• W2156899450 doi "https://doi.org/10.1093/infdis/jiu194" @default.
• W2156899450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4156136" @default.
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• W2156899450 hasPublicationYear "2014" @default.
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