FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156899867> ?p ?o ?g. }

• W2156899867 endingPage "2968" @default.
• W2156899867 startingPage "2963" @default.
• W2156899867 abstract "Right ventricular (RV) fibrosis is common in patients with repaired tetralogy of Fallot (rTOF). Although accumulating evidence indicates the role of circulating biomarkers of collagen metabolism in left ventricular fibrosis, rTOF data are lacking. This study examined the expression profile and clinical relevance of circulating biomarkers of collagen type I metabolism in rTOF patients.Serum biomarkers of collagen type I synthesis (carboxy-terminal propeptide of procollagen type I, PICP), degradation (carboxy-terminal telopeptide of collagen type I, CITP), and enzymes regulating collagen degradation (matrix metalloproteinases, and type I tissue inhibitor, TIMP-1) were measured in 70 rTOF and 91 control adults. All patients had complete clinical data and received cardiovascular magnetic resonance scans with late gadolinium enhancement (LGE).Compared to the controls, rTOF patients had higher PICP levels (p<0.001), PICP:CITP ratios (p<0.001), and TIMP-1 concentrations (p<0.001). Increasing PICP levels correlated with higher RV LGE scores (r=0.427, p<0.001), lower VO2max (r=-0.428, p=0.002), and larger RV volumes. Furthermore, stepwise multivariate linear regression analysis identified RV end-diastolic volume index >150mL/m(2) (β=40.52, p=0.016), RV LGE score (β=3.94, p=0.008), and age (β=-1.77, p=0.011) as independent correlates of circulating PICP levels.Patients with rTOF exhibited a profibrotic state with excessive collagen type I synthesis and dysregulated degradation. Elevated circulating PICP levels might reflect RV fibrosis, and link to adverse markers of clinical outcome." @default.
• W2156899867 created "2016-06-24" @default.
• W2156899867 creator A5003296270 @default.
• W2156899867 creator A5007976059 @default.
• W2156899867 creator A5008253139 @default.
• W2156899867 creator A5011512969 @default.
• W2156899867 creator A5019719023 @default.
• W2156899867 creator A5020586243 @default.
• W2156899867 creator A5025856135 @default.
• W2156899867 creator A5026656473 @default.
• W2156899867 creator A5032534545 @default.
• W2156899867 creator A5036428672 @default.
• W2156899867 creator A5040705062 @default.
• W2156899867 creator A5061317676 @default.
• W2156899867 creator A5063034756 @default.
• W2156899867 creator A5087358491 @default.
• W2156899867 date "2013-09-01" @default.
• W2156899867 modified "2023-10-18" @default.
• W2156899867 title "Circulating biomarkers of collagen type I metabolism mark the right ventricular fibrosis and adverse markers of clinical outcome in adults with repaired tetralogy of Fallot" @default.
• W2156899867 cites W1676600749 @default.
• W2156899867 cites W1785183744 @default.
• W2156899867 cites W1997120751 @default.
• W2156899867 cites W1998799472 @default.
• W2156899867 cites W2001984460 @default.
• W2156899867 cites W2024752964 @default.
• W2156899867 cites W2035558897 @default.
• W2156899867 cites W2049877803 @default.
• W2156899867 cites W2063439326 @default.
• W2156899867 cites W2069263823 @default.
• W2156899867 cites W2084685406 @default.
• W2156899867 cites W2096174447 @default.
• W2156899867 cites W2106493153 @default.
• W2156899867 cites W2108556871 @default.
• W2156899867 cites W2116481517 @default.
• W2156899867 cites W2119764477 @default.
• W2156899867 cites W2121179755 @default.
• W2156899867 cites W2124094285 @default.
• W2156899867 cites W2130120331 @default.
• W2156899867 cites W2132401137 @default.
• W2156899867 cites W2132602690 @default.
• W2156899867 cites W2162211311 @default.
• W2156899867 cites W2164901837 @default.
• W2156899867 cites W2168777122 @default.
• W2156899867 cites W2169821142 @default.
• W2156899867 cites W2171981556 @default.
• W2156899867 cites W2412218064 @default.
• W2156899867 doi "https://doi.org/10.1016/j.ijcard.2012.08.059" @default.
• W2156899867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22999338" @default.
• W2156899867 hasPublicationYear "2013" @default.
• W2156899867 type Work @default.
• W2156899867 sameAs 2156899867 @default.
• W2156899867 citedByCount "28" @default.
• W2156899867 countsByYear W21568998672014 @default.
• W2156899867 countsByYear W21568998672015 @default.
• W2156899867 countsByYear W21568998672016 @default.
• W2156899867 countsByYear W21568998672017 @default.
• W2156899867 countsByYear W21568998672018 @default.
• W2156899867 countsByYear W21568998672020 @default.
• W2156899867 countsByYear W21568998672022 @default.
• W2156899867 countsByYear W21568998672023 @default.
• W2156899867 crossrefType "journal-article" @default.
• W2156899867 hasAuthorship W2156899867A5003296270 @default.
• W2156899867 hasAuthorship W2156899867A5007976059 @default.
• W2156899867 hasAuthorship W2156899867A5008253139 @default.
• W2156899867 hasAuthorship W2156899867A5011512969 @default.
• W2156899867 hasAuthorship W2156899867A5019719023 @default.
• W2156899867 hasAuthorship W2156899867A5020586243 @default.
• W2156899867 hasAuthorship W2156899867A5025856135 @default.
• W2156899867 hasAuthorship W2156899867A5026656473 @default.
• W2156899867 hasAuthorship W2156899867A5032534545 @default.
• W2156899867 hasAuthorship W2156899867A5036428672 @default.
• W2156899867 hasAuthorship W2156899867A5040705062 @default.
• W2156899867 hasAuthorship W2156899867A5061317676 @default.
• W2156899867 hasAuthorship W2156899867A5063034756 @default.
• W2156899867 hasAuthorship W2156899867A5087358491 @default.
• W2156899867 hasBestOaLocation W21568998672 @default.
• W2156899867 hasConcept C109523444 @default.
• W2156899867 hasConcept C125870589 @default.
• W2156899867 hasConcept C126322002 @default.
• W2156899867 hasConcept C131075544 @default.
• W2156899867 hasConcept C134018914 @default.
• W2156899867 hasConcept C160160445 @default.
• W2156899867 hasConcept C164705383 @default.
• W2156899867 hasConcept C181199279 @default.
• W2156899867 hasConcept C2778198053 @default.
• W2156899867 hasConcept C2778646171 @default.
• W2156899867 hasConcept C2779537366 @default.
• W2156899867 hasConcept C2780074459 @default.
• W2156899867 hasConcept C2780559512 @default.
• W2156899867 hasConcept C2780644872 @default.
• W2156899867 hasConcept C2781197716 @default.
• W2156899867 hasConcept C3018763269 @default.
• W2156899867 hasConcept C55493867 @default.
• W2156899867 hasConcept C63363279 @default.
• W2156899867 hasConcept C64348721 @default.
• W2156899867 hasConcept C71924100 @default.
• W2156899867 hasConcept C86803240 @default.
• W2156899867 hasConcept C90924648 @default.

• next