FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156937303> ?p ?o ?g. }

• W2156937303 endingPage "377" @default.
• W2156937303 startingPage "370" @default.
• W2156937303 abstract "Hypertension and aging are both recognized to increase aortic stiffness, but their interactions are not completely understood. Most previous studies have attributed increased aortic stiffness to changes in extracellular matrix proteins that alter the mechanical properties of the vascular wall. Alternatively, we hypothesized that a significant component of increased vascular stiffness in hypertension is due to changes in the mechanical and adhesive properties of vascular smooth muscle cells, and that aging would augment the contribution from vascular smooth muscle cells when compared with the extracellular matrix. Accordingly, we studied aortic stiffness in young (16-week-old) and old (64-week-old) spontaneously hypertensive rats and Wistar–Kyoto wild-type controls. Systolic and pulse pressures were significantly increased in young spontaneously hypertensive rats when compared with young Wistar–Kyoto rats, and these continued to rise in old spontaneously hypertensive rats when compared with age-matched controls. Excised aortic ring segments exhibited significantly greater elastic moduli in both young and old spontaneously hypertensive rats versus Wistar–Kyoto rats. were isolated from the thoracic aorta, and stiffness and adhesion to fibronectin were measured by atomic force microscopy. Hypertension increased both vascular smooth muscle cell stiffness and vascular smooth muscle cell adhesion, and these increases were both augmented with aging. By contrast, hypertension did not affect histological measures of aortic collagen and elastin, which were predominantly changed by aging. These findings support the concept that stiffness and adhesive properties of vascular smooth muscle cells are novel mechanisms contributing to the increased aortic stiffness occurring with hypertension superimposed on aging." @default.
• W2156937303 created "2016-06-24" @default.
• W2156937303 creator A5005020744 @default.
• W2156937303 creator A5015477541 @default.
• W2156937303 creator A5034583499 @default.
• W2156937303 creator A5051551818 @default.
• W2156937303 creator A5056890673 @default.
• W2156937303 creator A5071689177 @default.
• W2156937303 creator A5072771199 @default.
• W2156937303 creator A5075566935 @default.
• W2156937303 date "2015-02-01" @default.
• W2156937303 modified "2023-10-12" @default.
• W2156937303 title "Augmented Vascular Smooth Muscle Cell Stiffness and Adhesion When Hypertension Is Superimposed on Aging" @default.
• W2156937303 cites W1499471108 @default.
• W2156937303 cites W1511614609 @default.
• W2156937303 cites W1626890019 @default.
• W2156937303 cites W1979049477 @default.
• W2156937303 cites W1987730138 @default.
• W2156937303 cites W1989654483 @default.
• W2156937303 cites W1991253285 @default.
• W2156937303 cites W1993708187 @default.
• W2156937303 cites W2002909243 @default.
• W2156937303 cites W2009798374 @default.
• W2156937303 cites W2024264687 @default.
• W2156937303 cites W2027967596 @default.
• W2156937303 cites W2034110426 @default.
• W2156937303 cites W2034246871 @default.
• W2156937303 cites W2042391189 @default.
• W2156937303 cites W2047241592 @default.
• W2156937303 cites W2049231617 @default.
• W2156937303 cites W2058381455 @default.
• W2156937303 cites W2069374420 @default.
• W2156937303 cites W2084249743 @default.
• W2156937303 cites W2084642988 @default.
• W2156937303 cites W2092641691 @default.
• W2156937303 cites W2094708153 @default.
• W2156937303 cites W2097286797 @default.
• W2156937303 cites W2103782586 @default.
• W2156937303 cites W2104953243 @default.
• W2156937303 cites W2105908700 @default.
• W2156937303 cites W2106599269 @default.
• W2156937303 cites W2125047490 @default.
• W2156937303 cites W2126284874 @default.
• W2156937303 cites W2128512270 @default.
• W2156937303 cites W2138626577 @default.
• W2156937303 cites W2140812062 @default.
• W2156937303 cites W2144120465 @default.
• W2156937303 cites W2146038929 @default.
• W2156937303 cites W2156286892 @default.
• W2156937303 cites W2161772172 @default.
• W2156937303 cites W2166067680 @default.
• W2156937303 cites W2319461447 @default.
• W2156937303 doi "https://doi.org/10.1161/hypertensionaha.114.04456" @default.
• W2156937303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4289111" @default.
• W2156937303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25452471" @default.
• W2156937303 hasPublicationYear "2015" @default.
• W2156937303 type Work @default.
• W2156937303 sameAs 2156937303 @default.
• W2156937303 citedByCount "103" @default.
• W2156937303 countsByYear W21569373032015 @default.
• W2156937303 countsByYear W21569373032016 @default.
• W2156937303 countsByYear W21569373032017 @default.
• W2156937303 countsByYear W21569373032018 @default.
• W2156937303 countsByYear W21569373032019 @default.
• W2156937303 countsByYear W21569373032020 @default.
• W2156937303 countsByYear W21569373032021 @default.
• W2156937303 countsByYear W21569373032022 @default.
• W2156937303 countsByYear W21569373032023 @default.
• W2156937303 crossrefType "journal-article" @default.
• W2156937303 hasAuthorship W2156937303A5005020744 @default.
• W2156937303 hasAuthorship W2156937303A5015477541 @default.
• W2156937303 hasAuthorship W2156937303A5034583499 @default.
• W2156937303 hasAuthorship W2156937303A5051551818 @default.
• W2156937303 hasAuthorship W2156937303A5056890673 @default.
• W2156937303 hasAuthorship W2156937303A5071689177 @default.
• W2156937303 hasAuthorship W2156937303A5072771199 @default.
• W2156937303 hasAuthorship W2156937303A5075566935 @default.
• W2156937303 hasBestOaLocation W21569373031 @default.
• W2156937303 hasConcept C126322002 @default.
• W2156937303 hasConcept C134018914 @default.
• W2156937303 hasConcept C142724271 @default.
• W2156937303 hasConcept C159985019 @default.
• W2156937303 hasConcept C164705383 @default.
• W2156937303 hasConcept C178790620 @default.
• W2156937303 hasConcept C185592680 @default.
• W2156937303 hasConcept C189165786 @default.
• W2156937303 hasConcept C192562407 @default.
• W2156937303 hasConcept C2775850156 @default.
• W2156937303 hasConcept C2776864027 @default.
• W2156937303 hasConcept C2779372316 @default.
• W2156937303 hasConcept C2779395532 @default.
• W2156937303 hasConcept C2779869378 @default.
• W2156937303 hasConcept C2779980429 @default.
• W2156937303 hasConcept C2992686903 @default.
• W2156937303 hasConcept C2993843704 @default.
• W2156937303 hasConcept C55493867 @default.
• W2156937303 hasConcept C71924100 @default.
• W2156937303 hasConcept C84393581 @default.

• next