FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2156943914> ?p ?o ?g. }

• W2156943914 endingPage "4786" @default.
• W2156943914 startingPage "4777" @default.
• W2156943914 abstract "A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over normal cells. Specifically, after rapid entry of glucose into cancer cells on the glucose transporter, the highly glycolytic phenotype is supported by hexokinase (primarily HK II) that is overexpressed and bound to the outer mitochondrial membrane via the porin-like protein voltage-dependent anion channel (VDAC). This protein and the adenine nucleotide transporter move ATP, newly synthesized by the inner membrane located ATP synthase, to active sites on HK II. The abundant amounts of HK II bind both the ATP and the incoming glucose producing the product glucose-6-phosphate, also at an elevated rate. This critical metabolite then serves both as a biosynthetic precursor to support cell proliferation and as a precursor for lactic acid, the latter exiting cancer cells causing an unfavorable environment for normal cells. Although helping facilitate this chemical warfare, HK II via its mitochondrial location also suppresses the death of cancer cells, thus increasing their possibility for metastasis and the ultimate death of the human host. For these reasons, targeting this key enzyme is currently being investigated in several laboratories in a strategy to develop novel therapies that may turn the tide on the continuing struggle to find effective cures for cancer. One such candidate is 3-bromopyruvate that has been shown recently to eradicate advanced stage, PET positive hepatocellular carcinomas in an animal model without apparent harm to the animals." @default.
• W2156943914 created "2016-06-24" @default.
• W2156943914 creator A5014258871 @default.
• W2156943914 creator A5030723056 @default.
• W2156943914 creator A5090340342 @default.
• W2156943914 date "2006-08-07" @default.
• W2156943914 modified "2023-10-02" @default.
• W2156943914 title "Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria" @default.
• W2156943914 cites W12017206 @default.
• W2156943914 cites W1559768539 @default.
• W2156943914 cites W1575666495 @default.
• W2156943914 cites W1579732580 @default.
• W2156943914 cites W1605149237 @default.
• W2156943914 cites W163059720 @default.
• W2156943914 cites W1644794975 @default.
• W2156943914 cites W1669473535 @default.
• W2156943914 cites W171513169 @default.
• W2156943914 cites W1832561515 @default.
• W2156943914 cites W1912085582 @default.
• W2156943914 cites W1913661233 @default.
• W2156943914 cites W1944408908 @default.
• W2156943914 cites W1950485111 @default.
• W2156943914 cites W1967644185 @default.
• W2156943914 cites W1968112618 @default.
• W2156943914 cites W1971859682 @default.
• W2156943914 cites W1972414420 @default.
• W2156943914 cites W1975227141 @default.
• W2156943914 cites W1975724297 @default.
• W2156943914 cites W1978249092 @default.
• W2156943914 cites W1979841879 @default.
• W2156943914 cites W1981079102 @default.
• W2156943914 cites W1981575376 @default.
• W2156943914 cites W1981810393 @default.
• W2156943914 cites W1984547206 @default.
• W2156943914 cites W1985286636 @default.
• W2156943914 cites W1988873376 @default.
• W2156943914 cites W1988917342 @default.
• W2156943914 cites W1991726361 @default.
• W2156943914 cites W1994186363 @default.
• W2156943914 cites W1994442108 @default.
• W2156943914 cites W1997055993 @default.
• W2156943914 cites W1999401753 @default.
• W2156943914 cites W2001144536 @default.
• W2156943914 cites W2001196593 @default.
• W2156943914 cites W2004139620 @default.
• W2156943914 cites W2005310276 @default.
• W2156943914 cites W2010953153 @default.
• W2156943914 cites W2012498962 @default.
• W2156943914 cites W2014086933 @default.
• W2156943914 cites W2014949933 @default.
• W2156943914 cites W2019789647 @default.
• W2156943914 cites W2021924465 @default.
• W2156943914 cites W2025562766 @default.
• W2156943914 cites W2027133675 @default.
• W2156943914 cites W2027817200 @default.
• W2156943914 cites W2029222949 @default.
• W2156943914 cites W2040583712 @default.
• W2156943914 cites W2042982552 @default.
• W2156943914 cites W2045102424 @default.
• W2156943914 cites W2048609504 @default.
• W2156943914 cites W2054076706 @default.
• W2156943914 cites W2054996065 @default.
• W2156943914 cites W2055063491 @default.
• W2156943914 cites W2069960667 @default.
• W2156943914 cites W2071493016 @default.
• W2156943914 cites W2081826708 @default.
• W2156943914 cites W2083770619 @default.
• W2156943914 cites W2084248702 @default.
• W2156943914 cites W2084314658 @default.
• W2156943914 cites W2086900431 @default.
• W2156943914 cites W2087900954 @default.
• W2156943914 cites W2089362829 @default.
• W2156943914 cites W2090632954 @default.
• W2156943914 cites W2094044245 @default.
• W2156943914 cites W2097347505 @default.
• W2156943914 cites W2100262552 @default.
• W2156943914 cites W2103716630 @default.
• W2156943914 cites W2104682444 @default.
• W2156943914 cites W2113559991 @default.
• W2156943914 cites W2121727754 @default.
• W2156943914 cites W2125698979 @default.
• W2156943914 cites W2129153646 @default.
• W2156943914 cites W2130250535 @default.
• W2156943914 cites W2146885685 @default.
• W2156943914 cites W2152720583 @default.
• W2156943914 cites W2157561719 @default.
• W2156943914 cites W2162033191 @default.
• W2156943914 cites W2168330194 @default.
• W2156943914 cites W2321452523 @default.
• W2156943914 cites W2341615229 @default.
• W2156943914 cites W2344663917 @default.
• W2156943914 cites W2398357503 @default.
• W2156943914 cites W2400264581 @default.
• W2156943914 cites W2430233533 @default.
• W2156943914 cites W302327703 @default.
• W2156943914 cites W3170423020 @default.
• W2156943914 cites W41376349 @default.
• W2156943914 cites W4210472171 @default.

• next