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- W21569453 endingPage "132" @default.
- W21569453 startingPage "121" @default.
- W21569453 abstract "The regulation of bone metabolism continues to be an area of intense investigation, with recent evidence indicating a potential contribution from the neural system. In particular, the neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has been hypothesized to play a role in skeletal metabolism via its transporter (5-HTT). The 5-HTT is a plasma membrane transporter that is highly specific for the uptake of extracellular 5-HT, thereby facilitating the intracellular storage and/or degradation of 5-HT. The 5-HTT is clinically important as it is the key target of pharmaceutical agents aimed at treating affective disorders, such as major depressive disorder. By antagonizing the 5-HTT, selective serotonin reuptake inhibitors (SSRIs) potentiate 5-HT activity and effectively relieve the symptoms of depression. However, questions have been raised regarding the potential skeletal effects of SSRIs given the recent identification of a functional 5-HTT and functional 5-HT receptors in bone cells. This paper discusses the preclinical evidence for the skeletal effects of 5-HT and the inhibition of the 5-HTT. In particular, it discusses the: (1) role of 5-HT and the function of the 5-HTT; (2) presence of functional 5-HTTs in bone; (3) potential sources and response mechanisms for 5-HT in bone, and; (4) in vitro and in vivo skeletal effects of 5-HT and 5-HTT inhibition." @default.
- W21569453 created "2016-06-24" @default.
- W21569453 creator A5001698968 @default.
- W21569453 creator A5006109181 @default.
- W21569453 date "2008-04-01" @default.
- W21569453 modified "2023-09-26" @default.
- W21569453 title "Skeletal effects of serotonin (5-hydroxytryptamine) transporter inhibition: evidence from in vitro and animal-based studies." @default.
- W21569453 cites W107472485 @default.
- W21569453 cites W139443835 @default.
- W21569453 cites W1521210328 @default.
- W21569453 cites W1525741126 @default.
- W21569453 cites W175660244 @default.
- W21569453 cites W185086502 @default.
- W21569453 cites W1907864108 @default.
- W21569453 cites W1963690512 @default.
- W21569453 cites W1963910480 @default.
- W21569453 cites W1965933091 @default.
- W21569453 cites W1969144895 @default.
- W21569453 cites W1972088939 @default.
- W21569453 cites W1976114760 @default.
- W21569453 cites W1976365299 @default.
- W21569453 cites W1977033986 @default.
- W21569453 cites W1984516711 @default.
- W21569453 cites W1987972424 @default.
- W21569453 cites W1989796311 @default.
- W21569453 cites W1994664645 @default.
- W21569453 cites W1997508587 @default.
- W21569453 cites W2005159512 @default.
- W21569453 cites W2008119750 @default.
- W21569453 cites W2011697324 @default.
- W21569453 cites W2011766130 @default.
- W21569453 cites W2011767937 @default.
- W21569453 cites W2013255360 @default.
- W21569453 cites W2014001501 @default.
- W21569453 cites W2014711343 @default.
- W21569453 cites W2014814979 @default.
- W21569453 cites W2015356887 @default.
- W21569453 cites W2015866099 @default.
- W21569453 cites W2035339470 @default.
- W21569453 cites W2035663126 @default.
- W21569453 cites W2037596036 @default.
- W21569453 cites W2042156452 @default.
- W21569453 cites W2042903064 @default.
- W21569453 cites W2043471821 @default.
- W21569453 cites W2051560210 @default.
- W21569453 cites W2052110444 @default.
- W21569453 cites W2062528505 @default.
- W21569453 cites W2062634104 @default.
- W21569453 cites W2066067450 @default.
- W21569453 cites W2071809025 @default.
- W21569453 cites W2074506892 @default.
- W21569453 cites W2074571415 @default.
- W21569453 cites W2078052498 @default.
- W21569453 cites W2080308963 @default.
- W21569453 cites W2085101124 @default.
- W21569453 cites W2090973045 @default.
- W21569453 cites W2091578240 @default.
- W21569453 cites W2092261616 @default.
- W21569453 cites W2092465977 @default.
- W21569453 cites W2095866838 @default.
- W21569453 cites W2097785193 @default.
- W21569453 cites W2101372256 @default.
- W21569453 cites W2103880802 @default.
- W21569453 cites W2104128554 @default.
- W21569453 cites W2112561547 @default.
- W21569453 cites W2113010384 @default.
- W21569453 cites W2113404778 @default.
- W21569453 cites W2113638222 @default.
- W21569453 cites W2117569876 @default.
- W21569453 cites W2117575931 @default.
- W21569453 cites W2118943047 @default.
- W21569453 cites W2121920106 @default.
- W21569453 cites W2122185538 @default.
- W21569453 cites W2125027724 @default.
- W21569453 cites W2125354005 @default.
- W21569453 cites W2130941553 @default.
- W21569453 cites W2131257296 @default.
- W21569453 cites W2132167094 @default.
- W21569453 cites W2132681528 @default.
- W21569453 cites W2133787329 @default.
- W21569453 cites W2136344894 @default.
- W21569453 cites W2137027390 @default.
- W21569453 cites W2137332217 @default.
- W21569453 cites W2138579314 @default.
- W21569453 cites W2140505555 @default.
- W21569453 cites W2147510409 @default.
- W21569453 cites W2153808678 @default.
- W21569453 cites W2159158135 @default.
- W21569453 cites W2159601487 @default.
- W21569453 cites W2162816738 @default.
- W21569453 cites W2167977201 @default.
- W21569453 cites W2168347208 @default.
- W21569453 cites W2411083510 @default.
- W21569453 cites W2412611266 @default.
- W21569453 cites W2418761934 @default.
- W21569453 cites W3148499377 @default.
- W21569453 cites W51813972 @default.
- W21569453 cites W576420132 @default.