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- W2156950701 abstract "So far, pentazocine iontophoresis has never been studied, although pentazocine is widely used in pain management. The purpose of this study was to determine whether pentazocine transportation through a cellophane membrane could be enhanced using square-wave alternating current (AC) iontophoresis with an adjusted duty cycle and dependence on the voltage and the duty cycle. Voltages of 10, 25 and 40 V with duty cycles of 50%, 51%, 52%, 53%, 54% and 55% were applied for 60 minutes at a high frequency of 1 MHz to diffusion cells on both sides of a cellophane membrane. The donor compartment was filled with a solution containing pentazocine. Square-wave AC iontophoresis with an adjusted duty cycle enhanced pentazocine transportation at higher voltages and duty cycles. These results suggested that the direct current (DC) component of the square-wave AC played an important role in enhancing pentazocine transportation despite changes in polarity at very high frequency of 1 MHz. The higher voltages and duty cycles induced a pH change. The practical electrical conditions that could be applied clinically were 25 V with a 54% duty cycle or 40 V with a 53% duty cycle." @default.
- W2156950701 created "2016-06-24" @default.
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- W2156950701 date "2008-03-01" @default.
- W2156950701 modified "2023-09-23" @default.
- W2156950701 title "Pentazocine transport by square-wave AC iontophoresis with an adjusted duty cycle." @default.
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- W2156950701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19845146" @default.
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